Sodium-dependent neutral amino acid transporter B(0)AT2

Last updated
SLC6A15
Identifiers
Aliases SLC6A15 , NTT73, SBAT1, V7-3, hv7-3, solute carrier family 6 member 15
External IDs OMIM: 607971 MGI: 2143484 HomoloGene: 18163 GeneCards: SLC6A15
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146335
NM_018057
NM_182767

NM_001252330
NM_175328
NM_001358821

RefSeq (protein)

NP_001139807
NP_060527
NP_877499

NP_001239259
NP_780537
NP_001345750

Location (UCSC) Chr 12: 84.86 – 84.91 Mb Chr 10: 103.37 – 103.42 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene. [5]

Contents

Function

SLC6A15 shows structural characteristics of an Na+ and Cl-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites. [6]

Clinical relevance

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region. [7]

Related Research Articles

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Excitatory amino acid transporter 1

Excitatory amino acid transporter 1 (EAAT1) is a protein that, in humans, is encoded by the SLC1A3 gene. EAAT1 is also often called the GLutamate ASpartate Transporter 1 (GLAST-1).

Neutral and basic amino acid transport protein rBAT

Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene.

A neurotransmitter sodium symporter (NSS) (TC# 2.A.22) is type of neurotransmitter transporter that catalyzes the uptake of a variety of neurotransmitters, amino acids, osmolytes and related nitrogenous substances by a solute:Na+ symport mechanism. The NSS family is a member of the APC superfamily. Its constituents have been found in bacteria, archaea and eukaryotes.

Excitatory amino acid transporter 3

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Neutral amino acid transporter B(0)

Neutral amino acid transporter B(0) is a protein that in humans is encoded by the SLC1A5 gene.

GABA transporter type 1

GABA transporter 1 (GAT1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.

Proton-coupled amino acid transporter 1

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.

Neutral amino acid transporter A

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.

Sodium- and chloride-dependent glycine transporter 2

Sodium- and chloride-dependent glycine transporter 2, also known as glycine transporter 2 (GlyT2), is a protein that in humans is encoded by the SLC6A5 gene.

Large neutral amino acids transporter small subunit 2

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.

SLC6A14

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.

SLC38A1

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.

Sodium-dependent neutral amino acid transporter B(0)AT1

Sodium-dependent neutral amino acid transporter B(0)AT1 is a protein that in humans is encoded by the SLC6A19 gene.

SLC6A18

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

Proton-coupled amino acid transporter 2

Proton-coupled amino acid transporter 2 is a protein which in humans is encoded by the SLC36A2 gene.

Plasma membrane monoamine transporter

The plasma membrane monoamine transporter (PMAT) is a low-affinity monoamine transporter protein which in humans is encoded by the SLC29A4 gene. It is known alternatively as the human equilibrative nucleoside transporter-4 (hENT4). Unlike other members of the ENT family, it is impermeable to most nucleosides, with the exception of the inhibitory neurotransmitter and ribonucleoside adenosine, which it is permeable to in a highly pH-dependent manner.

Y+L amino acid transporter 2

Y+L amino acid transporter 2, also known as cationic amino acid transporter, y+ system, is a protein that in humans is encoded by the SLC7A6 gene.

Asc-type amino acid transporter 1

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.

Monocarboxylate transporter 10

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000072041 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019894 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)".
  6. Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (Dec 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics. 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID   11112352.
  7. Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (Apr 2011). "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron. 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMC   3112053 . PMID   21521612.

Further reading