Cationic amino acid transporter 3

SLC7A3
Identifiers
Aliases	SLC7A3 , ATRC3, CAT-3, CAT3, solute carrier family 7 member 3
External IDs	OMIM: 300443 MGI: 1100521 HomoloGene: 56382 GeneCards: SLC7A3
Gene location (Human) Chr. X chromosome (human) [1] Band Xq13.1 Start 70,925,579 bp [1] End 70,931,125 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X C3- D Start 100,122,816 bp [2] End 100,129,626 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle thymus ganglionic eminence gastric mucosa deltoid muscle hypothalamus sperm smooth muscle tissue corpus epididymis caput epididymis Top expressed in dorsomedial hypothalamic nucleus otic placode ventral tegmental area paraventricular nucleus of hypothalamus lateral hypothalamus primitive streak ventromedial nucleus substantia nigra subiculum arcuate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function basic amino acid transmembrane transporter activity L-lysine transmembrane transporter activity amino acid transmembrane transporter activity transmembrane transporter activity L-ornithine transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane Biological process basic amino acid transmembrane transport L-lysine transmembrane transport L-alpha-amino acid transmembrane transport L-arginine transmembrane transport amino acid transport transmembrane transport L-arginine import across plasma membrane L-ornithine transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84889 11989 Ensembl ENSG00000165349 ENSMUSG00000031297 UniProt Q8WY07 P70423 RefSeq (mRNA) NM_032803 NM_001048164 NM_001301840 NM_007515 RefSeq (protein) NP_001041629 NP_116192 NP_001288769 NP_031541 Location (UCSC) Chr X: 70.93 – 70.93 Mb Chr X: 100.12 – 100.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene. ^{[5] [6]}

SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM] ^[6]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000165349 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031297 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI (Oct 2001). "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues". Biochemistry. 40 (41): 12387–94. doi:10.1021/bi011345c. PMID   11591158.
6. "Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3".

Further reading

• Hosokawa H, Sawamura T, Kobayashi S, et al. (1997). "Cloning and characterization of a brain-specific cationic amino acid transporter". J. Biol. Chem. 272 (13): 8717–22. doi: 10.1074/jbc.272.13.8717 . PMID   9079705.
• Ito K, Groudine M (1997). "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain". J. Biol. Chem. 272 (42): 26780–6. doi: 10.1074/jbc.272.42.26780 . PMID   9334265.
• Hosokawa H, Ninomiya H, Sawamura T, et al. (1999). "Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain". Brain Res. 838 (1–2): 158–65. doi:10.1016/S0006-8993(99)01686-8. PMID   10446328. S2CID   33405664.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gilles W, Vulcu SD, Liewald JF, et al. (2005). "Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3". Biochim. Biophys. Acta. 1668 (2): 234–9. doi:10.1016/j.bbamem.2004.12.011. PMID   15737334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Rotmann A, Vékony N, Gassner D, et al. (2006). "Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane". Biochem. J. 395 (1): 117–23. doi:10.1042/BJ20051558. PMC   1409692 . PMID   16332251.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.