Cationic amino acid transporter 4

SLC7A4
Identifiers
Aliases	SLC7A4 , CAT-4, CAT4, HCAT3, VH, solute carrier family 7 member 4
External IDs	OMIM: 603752; MGI: 2146512; HomoloGene: 20883; GeneCards: SLC7A4; OMA:SLC7A4 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.21 Start 21,028,718 bp [1] End 21,032,840 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A3 Start 17,389,882 bp [2] End 17,401,078 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis prefrontal cortex right hemisphere of cerebellum right adrenal gland right adrenal cortex gonad right frontal lobe left adrenal cortex hypothalamus Top expressed in dentate gyrus of hippocampal formation granule cell seminal vesicula superior frontal gyrus primary visual cortex parotid gland right ventricle hippocampus proper lacrimal gland Region I of hippocampus proper prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function basic amino acid transmembrane transporter activity transmembrane transporter activity amino acid transmembrane transporter activity Cellular component integral component of membrane membrane Biological process cellular amino acid metabolic process amino acid transport basic amino acid transmembrane transport transmembrane transport amino acid transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6545 224022 Ensembl ENSG00000099960 ENSMUSG00000022756 UniProt O43246 Q8BLQ7 RefSeq (mRNA) NM_004173 NM_144852 NM_001359891 NM_001359892 NM_001359893 RefSeq (protein) NP_004164 NP_659101 NP_001346820 NP_001346821 NP_001346822 Location (UCSC) Chr 22: 21.03 – 21.03 Mb Chr 16: 17.39 – 17.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cationic amino acid transporter 4 is a protein that in humans is encoded by the SLC7A4 gene. ^{[5] [6] [7]}

See also

• SLC7A4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

References

1. GRCh38: Ensembl release 89: ENSG00000099960 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022756 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sperandeo MP, Borsani G, Incerti B, Zollo M, Rossi E, Zuffardi O, Castaldo P, Taglialatela M, Andria G, Sebastio G (Aug 1998). "The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome". Genomics. 49 (2): 230–6. doi:10.1006/geno.1998.5252. hdl:11566/82078. PMID   9598310.
6. Hammermann R, Brunn G, Racke K (Oct 2001). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID   11665818. S2CID   30892800.
7. "Entrez Gene: SLC7A4 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4".

Further reading

• Muñoz L, Lasa A, Carricondo MT, et al. (2007). "Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia". Cytometry Part B. 72 (2): 96–102. doi: 10.1002/cyto.b.20149 . PMID   17051526.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wolf S, Janzen A, Vékony N, et al. (2002). "Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity". Biochem. J. 364 (Pt 3): 767–75. doi:10.1042/BJ20020084. PMC   1222626 . PMID   12049641.
• Neshat MN, Goodglick L, Lim K, Braun J (2000). "Mapping the B cell superantigen binding site for HIV-1 gp120 on a V(H)3 Ig". Int. Immunol. 12 (3): 305–12. doi: 10.1093/intimm/12.3.305 . PMID   10700465.
• Fischer M, Küppers R (1998). "Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes". Eur. J. Immunol. 28 (9): 2971–7. doi: 10.1002/(SICI)1521-4141(199809)28:09<2971::AID-IMMU2971>3.0.CO;2-3 . PMID   9754584.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.