Glucose-6-phosphate exchanger SLC37A1

Last updated
SLC37A1
Identifiers
Aliases SLC37A1 , G3PP, solute carrier family 37 member 1
External IDs OMIM: 608094 MGI: 2446181 HomoloGene: 70486 GeneCards: SLC37A1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018964
NM_001320537

NM_001242427
NM_153062

RefSeq (protein)

NP_001307466
NP_061837

NP_001229356
NP_694702

Location (UCSC) Chr 21: 42.5 – 42.58 Mb Chr 17: 31.51 – 31.57 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene. [5] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction. [6]

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis, [7] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced. [8]

Related Research Articles

<span class="mw-page-title-main">Ribosomal protein S6</span> Protein-coding gene in the species Homo sapiens

Ribosomal protein S6 is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.

<span class="mw-page-title-main">GPR171</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 171 is a protein that in humans is encoded by the GPR171 gene.

<span class="mw-page-title-main">G6PC</span> Protein-coding gene in the species Homo sapiens

Glucose-6-phosphatase, catalytic subunit is an enzyme that in humans is encoded by the G6PC gene.

<span class="mw-page-title-main">H6PD</span> Protein-coding gene in the species Homo sapiens

GDH/6PGL endoplasmic bifunctional protein is a protein that in humans is encoded by the H6PD gene.

<span class="mw-page-title-main">Carbohydrate-responsive element-binding protein</span> Protein-coding gene in the species Homo sapiens

Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the MLXIPL gene. The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA.

<span class="mw-page-title-main">SLC2A12</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

<span class="mw-page-title-main">SLC2A6</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.

<span class="mw-page-title-main">SLC2A9</span> Protein-coding gene in the species Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.

<span class="mw-page-title-main">Vesicular glutamate transporter 1</span> Protein-coding gene in the species Homo sapiens

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.

<span class="mw-page-title-main">Sodium-dependent phosphate transport protein 1</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

<span class="mw-page-title-main">SLC20A2</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transporter 2 is a protein that in humans is encoded by the SLC20A2 gene.

<span class="mw-page-title-main">Sodium-dependent phosphate transport protein 2C</span> Protein-coding gene in the species Homo sapiens

Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.

<span class="mw-page-title-main">DPM3</span> Protein-coding gene in the species Homo sapiens

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.

<span class="mw-page-title-main">G6PC3</span> Protein-coding gene in the species Homo sapiens

Glucose-6-phosphatase 3, also known as glucose-6-phosphatase beta, is an enzyme that in humans is encoded by the G6PC3 gene.

<span class="mw-page-title-main">DPM2</span> Protein-coding gene in the species Homo sapiens

Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene.

<span class="mw-page-title-main">KSR2</span> Protein-coding gene in the species Homo sapiens

The KSR2 gene is Kinase suppressor of ras 2 it is a protein that in humans is encoded by the KSR2 gene. KSR2 mutation effects in humans by obesity and because KSR2 gene reduces the ERK signaling and it reduces glucose and fatty acid oxidation. KSR2 mutation reduces the glucose and fatty acid oxidation process but it makes growth factor "Epidermal growth factor (EGF)" reaction more faster to simulate cell growth and KSR2 cause insulin resistance, KSA2 gene also regulates how the body uses the energy, and it usually causes type 2 diabetes.

<span class="mw-page-title-main">Calcium-binding mitochondrial carrier protein SCaMC-1</span> Protein-coding gene in the species Homo sapiens

Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.

<span class="mw-page-title-main">Glucose-6-phosphate exchanger SLC37A2</span> Biological protein

Glucose-6-phosphate exchanger SLC37A2 is a protein that in humans is encoded by the SLC37A2 gene.

<span class="mw-page-title-main">Sugar transporter SWEET1</span> Protein-coding gene in the species Homo sapiens

Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane protein that in humans is encoded by the SLC50A1 gene. SWEET1 is the sole transporter from the SLC50 (SWEET) gene family present in the genomes of most animal species, with the exception of the nematode Caenorhabditis elegans, which has seven.

<span class="mw-page-title-main">SLC45A1</span> Protein-coding gene in the species Homo sapiens

SLC45A1 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, such as glucose and sucrose (ii) perform secondary active transport in a proton-dependent manner.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160190 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024036 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1".
  6. "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein".
  7. Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY (2011). "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLOS ONE. 6 (9): e23157. Bibcode:2011PLoSO...623157P. doi: 10.1371/journal.pone.0023157 . PMC   3176764 . PMID   21949678.
  8. Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME (2016). "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics. 17 (1): 858. doi: 10.1186/s12864-016-3175-3 . PMC   5094043 . PMID   27809761.

Further reading