Long-chain fatty acid transport protein 4

SLC27A4
Identifiers
Aliases	SLC27A4 , ACSVL4, FATP4, IPS, solute carrier family 27 member 4
External IDs	OMIM: 604194; MGI: 1347347; HomoloGene: 68437; GeneCards: SLC27A4; OMA:SLC27A4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.11 Start 128,340,527 bp [1] End 128,361,470 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 B|2 20.64 cM Start 29,692,646 bp [2] End 29,707,534 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon jejunal mucosa duodenum skin of arm mucosa of ileum prefrontal cortex right frontal lobe skin of leg Brodmann area 9 Hypothalamus Top expressed in lip granulocyte jejunum duodenum ileum skin of external ear esophagus pontine nuclei skin of abdomen medial dorsal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function long-chain fatty acid-CoA ligase activity nucleotide binding fatty acid transmembrane transporter activity ligase activity catalytic activity very long-chain fatty acid-CoA ligase activity long-chain fatty acid transporter activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane plasma membrane microvillus brush border membrane endoplasmic reticulum Biological process lipid transport response to nutrient lipid metabolism medium-chain fatty acid transport very long-chain fatty acid metabolic process fatty acid transport fatty acid metabolic process long-chain fatty acid import into cell very long-chain fatty acid catabolic process metabolism long-chain fatty acid metabolic process skin development long-chain fatty acid transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10999 26569 Ensembl ENSG00000167114 ENSMUSG00000059316 UniProt Q6P1M0 Q91VE0 RefSeq (mRNA) NM_005094 NM_011989 RefSeq (protein) NP_005085 NP_005085.2 NP_036119 Location (UCSC) Chr 9: 128.34 – 128.36 Mb Chr 2: 29.69 – 29.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene. ^{[5] [6]} This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A. ^[7] It is debated whether it is also a fatty acid transporter at the plasma membrane. ^[8]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000167114 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059316 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fitscher BA, Riedel HD, Young KC, Stremmel W (Dec 1998). "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 381–5. doi:10.1016/s0167-4781(98)00231-0. PMID   9878842.
6. "Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4".
7. Hall AM, Wiczer BM, Herrmann T, Stremmel W, Bernlohr DA (Mar 2005). "Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice". The Journal of Biological Chemistry. 280 (12): 11948–54. doi: 10.1074/jbc.M412629200 . PMID   15653672.
8. Watkins PA (Jan 2008). "Very-long-chain acyl-CoA synthetases". The Journal of Biological Chemistry. 283 (4): 1773–7. doi: 10.1074/jbc.R700037200 . PMID   18024425.

Further reading

• Hirsch D, Stahl A, Lodish HF (Jul 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi: 10.1073/pnas.95.15.8625 . PMC   21126 . PMID   9671728.
• Stahl A, Hirsch DJ, Gimeno RE, Punreddy S, Ge P, Watson N, Patel S, Kotler M, Raimondi A, Tartaglia LA, Lodish HF (Sep 1999). "Identification of the major intestinal fatty acid transport protein". Molecular Cell. 4 (3): 299–308. doi: 10.1016/S1097-2765(00)80332-9 . PMID   10518211.
• Gertow K, Bellanda M, Eriksson P, Boquist S, Hamsten A, Sunnerhagen M, Fisher RM (Jan 2004). "Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome". The Journal of Clinical Endocrinology and Metabolism. 89 (1): 392–9. doi: 10.1210/jc.2003-030682 . hdl: 11577/1331563 . PMID   14715877.
• Gertow K, Pietiläinen KH, Yki-Järvinen H, Kaprio J, Rissanen A, Eriksson P, Hamsten A, Fisher RM (Jun 2004). "Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance". Diabetologia. 47 (6): 1118–25. doi: 10.1007/s00125-004-1417-4 . PMID   15168018.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, Watkins PA, Stremmel W, Füllekrug J (Nov 2006). "Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4". Journal of Cell Science. 119 (Pt 22): 4678–88. doi: 10.1242/jcs.03280 . PMID   17062637.