Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by the SLC25A17 gene. [5] [6]
Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by the SLC25A17 gene. [5] [6]
SLC25A17 is a peroxisomal membrane protein that belongs to the family of mitochondrial solute carriers.[supplied by OMIM] [6]
A peroxisome (IPA: [pɛɜˈɹɒksɪˌsoʊm]) is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. Peroxisomes are oxidative organelles. Frequently, molecular oxygen serves as a co-substrate, from which hydrogen peroxide (H2O2) is then formed. Peroxisomes owe their name to hydrogen peroxide generating and scavenging activities. They perform key roles in lipid metabolism and the conversion of reactive oxygen species. Peroxisomes are involved in the catabolism of very long chain fatty acids, branched chain fatty acids, bile acid intermediates (in the liver), D-amino acids, and polyamines, the reduction of reactive oxygen species – specifically hydrogen peroxide – and the biosynthesis of plasmalogens, i.e., ether phospholipids critical for the normal function of mammalian brains and lungs. They also contain approximately 10% of the total activity of two enzymes (Glucose-6-phosphate dehydrogenase and 6-Phosphogluconate dehydrogenase) in the pentose phosphate pathway, which is important for energy metabolism. It is vigorously debated whether peroxisomes are involved in isoprenoid and cholesterol synthesis in animals. Other known peroxisomal functions include the glyoxylate cycle in germinating seeds ("glyoxysomes"), photorespiration in leaves, glycolysis in trypanosomes ("glycosomes"), and methanol and/or amine oxidation and assimilation in some yeasts.
Peroxisomal targeting signal 1 receptor (PTS1R) is a protein that in humans is encoded by the PEX5 gene.
Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.
Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.
ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene.
Peroxisomal biogenesis factor 2 is a protein that in humans is encoded by the PEX2 gene.
Peroxisome assembly protein 12 is a protein that in humans is encoded by the PEX12 gene.
Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene. It located on chromosome 2 next to KIAA1841
Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the PEX3 gene.
Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.
Peroxisome assembly factor 2 is a protein that in humans is encoded by the PEX6 gene. PEX6 is an AAA ATPase that localizes to the peroxisome. PEX6 forms a hexamer with PEX1 and is recruited to the membrane by PEX26.
Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene. Alternative splicing results in two transcript variants encoding different isoforms.
ATP-binding cassette sub-family D member 2 is a membrane pump/transporter protein that in humans is encoded by the ABCD2 gene.
Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.
Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.
Calcium-binding mitochondrial carrier protein Aralar1 is a protein that in humans is encoded by the SLC25A12 gene. Aralar is an integral membrane protein located in the inner mitochondrial membrane. Its primary function as an antiporter is the transport of cytoplasmic glutamate with mitochondrial aspartate across the inner mitochondrial membrane, dependent on the binding of one calcium ion. Mutations in this gene cause early infantile epileptic encephalopathy 39 (EIEE39), symptomized by global hypomyelination of the central nervous system, refractory seizures, and neurodevelopmental impairment. This gene has connections to autism.
Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene. It is involved in the regulation of peroxisome abundance.
Peroxisomal membrane protein 11A is a protein that in humans is encoded by the PEX11A gene.
Peroxisomal membrane protein 4 is a protein that in humans is encoded by the PXMP4 gene.
Unc-93 homolog A is a protein that in humans is encoded by the UNC93A gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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