SLC45A3

SLC45A3
Identifiers
Aliases	SLC45A3 , IPCA-2, IPCA-6, IPCA-8, IPCA6, PCANAP2, PCANAP6, PCANAP8, PRST, solute carrier family 45 member 3
External IDs	OMIM: 605097; MGI: 1922082; HomoloGene: 23813; GeneCards: SLC45A3; OMA:SLC45A3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 205,657,851 bp [1] End 205,680,509 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 131,890,705 bp [2] End 131,910,707 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prostate C1 segment oocyte nasal epithelium secondary oocyte mucosa of ileum right lobe of liver spleen inferior ganglion of vagus nerve mucosa of transverse colon Top expressed in secondary oocyte primary oocyte zygote gastric mucosa pyloric antrum mucous cell of stomach epithelium of stomach egg cell lumbar spinal ganglion right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function sucrose:proton symporter activity sugar transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane Biological process transmembrane transport sucrose transport positive regulation of glucose metabolic process positive regulation of fatty acid biosynthetic process regulation of oligodendrocyte differentiation hexose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85414 212980 Ensembl ENSG00000158715 ENSMUSG00000026435 UniProt Q96JT2 Q8K0H7 RefSeq (mRNA) NM_033102 NM_001177628 NM_145977 RefSeq (protein) NP_149093 NP_001171099 NP_666089 Location (UCSC) Chr 1: 205.66 – 205.68 Mb Chr 1: 131.89 – 131.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene. ^{[5] [6] [7]}

SLC45A3 is expressed in a prostate-specific manner by normal tissues and at a significantly lower level in prostate tumor cell lines. Treatment of prostate cancer cell lines with androgens upregulates the expression of SLC45A3. ^[7]

Immunohistochemistry of prostein in metastatic prostate adenocarcinoma to a lymph node, showing cytoplasmic staining.

Regulation

There is evidence that the expression of SLC45A3 is regulated by the microRNA mir-126*. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000158715 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026435 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 45".
6. Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (December 1999). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes". Genome Research. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC   310991 . PMID   10613842.
7. Xu J, Kalos M, Stolk JA, Zasloff EJ, Zhang X, Houghton RL, et al. (February 2001). "Identification and characterization of prostein, a novel prostate-specific protein". Cancer Research. 61 (4): 1563–8. PMID   11245466.
8. Musiyenko A, Bitko V, Barik S (March 2008). "Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells". Journal of Molecular Medicine. 86 (3): 313–22. doi:10.1007/s00109-007-0296-9. PMC   3263384 . PMID   18193184.

Further reading

• Pflueger D, Rickman DS, Sboner A, Perner S, LaFargue CJ, Svensson MA, et al. (August 2009). "N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer". Neoplasia. 11 (8): 804–11. doi:10.1593/neo.09572. PMC   2713587 . PMID   19649210.
• Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, et al. (January 2008). "Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer". Cancer Research. 68 (1): 73–80. doi: 10.1158/0008-5472.CAN-07-5352 . PMID   18172298.
• Esgueva R, Perner S, J LaFargue C, Scheble V, Stephan C, Lein M, et al. (April 2010). "Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort". Modern Pathology. 23 (4): 539–46. doi:10.1038/modpathol.2009.193. PMC   2848699 . PMID   20118910.
• Friedman RS, Spies AG, Kalos M (April 2004). "Identification of naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate". European Journal of Immunology. 34 (4): 1091–101. doi: 10.1002/eji.200324768 . PMID   15048720.
• Maher CA, Kumar-Sinha C, Cao X, Kalyana-Sundaram S, Han B, Jing X, et al. (March 2009). "Transcriptome sequencing to detect gene fusions in cancer". Nature. 458 (7234): 97–101. Bibcode:2009Natur.458...97M. doi:10.1038/nature07638. PMC   2725402 . PMID   19136943.
• Musiyenko A, Bitko V, Barik S (March 2008). "Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells". Journal of Molecular Medicine. 86 (3): 313–22. doi:10.1007/s00109-007-0296-9. PMC   3263384 . PMID   18193184.
• Kiessling A, Stevanovic S, Füssel S, Weigle B, Rieger MA, Temme A, et al. (March 2004). "Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein". British Journal of Cancer. 90 (5): 1034–40. doi:10.1038/sj.bjc.6601642. PMC   2410218 . PMID   14997204.
• Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, et al. (December 2009). "Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease". Nature Genetics. 41 (12): 1303–7. doi:10.1038/ng.485. PMID   19915576. S2CID   205356259.
• Kalos M, Askaa J, Hylander BL, Repasky EA, Cai F, Vedvick T, et al. (August 2004). "Prostein expression is highly restricted to normal and malignant prostate tissues". The Prostate. 60 (3): 246–56. doi:10.1002/pros.20043. PMID   15176054. S2CID   24772512.
• Sheridan T, Herawi M, Epstein JI, Illei PB (September 2007). "The role of P501S and PSA in the diagnosis of metastatic adenocarcinoma of the prostate". The American Journal of Surgical Pathology. 31 (9): 1351–5. doi:10.1097/PAS.0b013e3180536678. PMID   17721190. S2CID   10247840.