SLC45A3

Last updated
SLC45A3
Identifiers
Aliases SLC45A3 , IPCA-2, IPCA-6, IPCA-8, IPCA6, PCANAP2, PCANAP6, PCANAP8, PRST, solute carrier family 45 member 3
External IDs OMIM: 605097 MGI: 1922082 HomoloGene: 23813 GeneCards: SLC45A3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033102

NM_001177628
NM_145977

RefSeq (protein)

NP_149093

NP_001171099
NP_666089

Location (UCSC) Chr 1: 205.66 – 205.68 Mb Chr 1: 131.89 – 131.91 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene. [5] [6] [7]

Contents

SLC45A3 is expressed in a prostate-specific manner by normal tissues and at a significantly lower level in prostate tumor cell lines. Treatment of prostate cancer cell lines with androgens upregulates the expression of SLC45A3. [7]

Immunohistochemistry of prostein in metastatic prostate adenocarcinoma to a lymph node, showing cytoplasmic staining. Immunohistochemistry of prostein in metastatic prostate adenocarcinoma.jpg
Immunohistochemistry of prostein in metastatic prostate adenocarcinoma to a lymph node, showing cytoplasmic staining.

Regulation

There is evidence that the expression of SLC45A3 is regulated by the microRNA mir-126*. [8]

Related Research Articles

Fusion gene

A fusion gene is a hybrid gene formed from two previously independent genes. It can occur as a result of translocation, interstitial deletion, or chromosomal inversion. Fusion genes have been found to be prevalent in all main types of human neoplasia. The identification of these fusion genes play a prominent role in being a diagnostic and prognostic marker.

NKX3-1 Protein-coding gene in the species Homo sapiens

Homeobox protein Nkx-3.1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3.1 is a protein that in humans is encoded by the NKX3-1 gene located on chromosome 8p. NKX3-1 is a prostatic tumor suppressor gene.

<i>ERG</i> (gene) Protein-coding gene in the species Homo sapiens

ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.

KLK4

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

ATBF1 Protein-coding gene in humans

Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene.

TMPRSS2 Protein-coding gene in the species Homo sapiens

Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene.

Zinc transporter ZIP1

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.

<i>EHF</i> (gene) Protein-coding gene in the species Homo sapiens

ETS homologous factor is a protein that in humans is encoded by the EHF gene. This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.

Zinc transporter 4

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.

Sodium/myo-inositol cotransporter Protein-coding gene in the species Homo sapiens

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.

ERGIC2

Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) is a gene located on human chromosome 12p11. It encodes a protein of 377 amino acid residues. ERGIC2 protein is also known as PTX1, CDA14 or Erv41.

ERGIC3

Endoplasmic reticulum-Golgi intermediate compartment protein 3 is a protein that in humans is encoded by the ERGIC3 gene. It has been reported to be regulated by micro RNAs and may be important in a cancer.

CUZD1

CUB and zona pellucida-like domain-containing protein 1 is a protein that in humans is encoded by the CUZD1 gene.

Large neutral amino acids transporter small subunit 3

Large neutral amino acids transporter small subunit 3 is a protein that in humans is encoded by the SLC43A1 gene.

Zinc transporter 1

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.

IRX5

Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.

FOXA1

Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene.

PCGEM1

Prostate-specific transcript 1 , also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer. In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.

ADP/ATP translocase 2 Protein-coding gene in the species Homo sapiens

ADP/ATP translocase 2 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome.

Zinc transporter ZIP12

Solute carrier family 39 member 12 is a protein that in humans is encoded by the SLC39A12 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000158715 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026435 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: solute carrier family 45".
  6. Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (December 1999). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes". Genome Research. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC   310991 . PMID   10613842.
  7. 1 2 Xu J, Kalos M, Stolk JA, Zasloff EJ, Zhang X, Houghton RL, et al. (February 2001). "Identification and characterization of prostein, a novel prostate-specific protein". Cancer Research. 61 (4): 1563–8. PMID   11245466.
  8. Musiyenko A, Bitko V, Barik S (March 2008). "Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells". Journal of Molecular Medicine. 86 (3): 313–22. doi:10.1007/s00109-007-0296-9. PMC   3263384 . PMID   18193184.

Further reading