Sodium/hydrogen exchanger 10

SLC9C1
Identifiers
Aliases	SLC9C1 , NHE, SLC9A10, sperm-NHE, NHE-10, solute carrier family 9 member C1
External IDs	OMIM: 612738; MGI: 2685456; HomoloGene: 19505; GeneCards: SLC9C1; OMA:SLC9C1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.2 Start 112,140,898 bp [1] End 112,294,227 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B5 Start 45,355,672 bp [2] End 45,427,364 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle body of pancreas left testis right testis gonad skin of abdomen skin of leg left ventricle apex of heart left lobe of thyroid gland Top expressed in spermatocyte spermatid testicle islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function solute:proton antiporter activity antiporter activity potassium:proton antiporter activity sodium:proton antiporter activity ion channel activity Cellular component integral component of membrane cell projection motile cilium cilium membrane plasma membrane Biological process multicellular organism development proton transmembrane transport flagellated sperm motility cell differentiation cation transport ion transport spermatogenesis sodium ion transport regulation of intracellular pH sodium ion import across plasma membrane potassium ion transmembrane transport transmembrane transport anion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 285335 208169 Ensembl ENSG00000172139 ENSG00000285044 ENSMUSG00000033210 UniProt Q4G0N8 Q6UJY2 RefSeq (mRNA) NM_183061 NM_001320531 NM_198106 RefSeq (protein) NP_001307460 NP_898884 NP_932774 Location (UCSC) Chr 3: 112.14 – 112.29 Mb Chr 16: 45.36 – 45.43 Mb PubMed search [3] [4]
Wikidata
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Sodium/hydrogen exchanger 10, also known as solute carrier family 9 member 10, is a protein that in humans is encoded by the SLC9A10 gene. ^{[5] [6]}

Function

SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family and is required for male fertility and sperm motility. ^{[5] [7]}

References

1. ENSG00000285044 GRCh38: Ensembl release 89: ENSG00000172139, ENSG00000285044 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033210 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 9".
6. Oduru S, Campbell JL, Karri S, Hendry WJ, Khan SA, Williams SC (June 2003). "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs". BMC Genomics. 4 (1): 22. doi: 10.1186/1471-2164-4-22 . PMC   161800 . PMID   12783626.
7. Wang D, King SM, Quill TA, Doolittle LK, Garbers DL (December 2003). "A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility". Nature Cell Biology. 5 (12): 1117–22. doi:10.1038/ncb1072. PMID   14634667. S2CID   12912080.