Sodium/hydrogen exchanger 10

SLC9C1
Identifiers
Aliases	SLC9C1 , NHE, SLC9A10, sperm-NHE, NHE-10, solute carrier family 9 member C1
External IDs	OMIM: 612738 MGI: 2685456 HomoloGene: 19505 GeneCards: SLC9C1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	112,294,227 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	45,427,364 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; testicle; ; skin of abdomen; ; left ventricle; ; left lobe of thyroid gland; ; islet of Langerhans; ; right lobe of thyroid gland; ; Achilles tendon; ; body of stomach; ; rectum;
	Top expressed in
	spermatocyte; ; spermatid; ; testicle; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	solute:proton antiporter activity ; antiporter activity ; potassium:proton antiporter activity ; sodium:proton antiporter activity ; ion channel activity ;
Cellular component	integral component of membrane ; cell projection ; motile cilium ; cilium ; membrane ; plasma membrane ;
Biological process	multicellular organism development ; proton transmembrane transport ; flagellated sperm motility ; cell differentiation ; cation transport ; ion transport ; spermatogenesis ; sodium ion transport ; regulation of intracellular pH ; sodium ion import across plasma membrane ; potassium ion transmembrane transport ; transmembrane transport ; anion transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	285335
	208169
	ENSG00000172139 ; ENSG00000285044
	ENSMUSG00000033210
	Q4G0N8
	Q6UJY2
	NM_183061 ; NM_001320531
	NM_198106
	NP_001307460 ; NP_898884
	NP_932774
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Sodium/hydrogen exchanger 10, also known as solute carrier family 9 member 10, is a protein that in humans is encoded by the SLC9A10 gene.^[5]^[6]

Function

SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family and is required for male fertility and sperm motility.^[5]^[7]

Related Research Articles

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.

Sodium/hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.

Sodium/hydrogen exchanger 11, also known as solute carrier family 9, member 11, is a protein that in humans is encoded by the SLC9A11 gene. SLC9A11 is a member of the sodium-hydrogen exchanger (NHE) family.

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

Solute carrier family 13 (sodium-dependent citrate transporter), member 5 also known as the Na⁺/citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene. It is the mammalian homolog of the fly Indy gene.

Solute carrier family 8, member B1 is a protein that in humans is encoded by the SLC8B1 gene.

Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.

Glucose-6-phosphate exchanger SLC37A2 is a protein that in humans is encoded by the SLC37A2 gene.

Sodium/potassium/calcium exchanger 4 also known as solute carrier family 24 member 4 is a protein that in humans is encoded by the SLC24A4 gene.

Sodium-dependent phosphate transport protein 2A, also known as Na⁺-P_i cotransporter 2a (NaPi-2a), is a protein in humans that is encoded by the SLC34A1 gene. This gene encodes a member of the type II sodium-phosphate cotransporter family.

Solute carrier family 38 member 5 is a protein that in humans is encoded by the SLC38A5 gene.

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene. SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.

References

1 2 3 ENSG00000285044 GRCh38: Ensembl release 89: ENSG00000172139, ENSG00000285044 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033210 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: solute carrier family 9".
↑ Oduru S, Campbell JL, Karri S, Hendry WJ, Khan SA, Williams SC (June 2003). "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs". BMC Genomics. 4 (1): 22. doi:10.1186/1471-2164-4-22. PMC 161800 . PMID 12783626.
↑ Wang D, King SM, Quill TA, Doolittle LK, Garbers DL (December 2003). "A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility". Nature Cell Biology. 5 (12): 1117–22. doi:10.1038/ncb1072. PMID 14634667. S2CID 12912080.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000285044 GRCh38: Ensembl release 89: ENSG00000172139, ENSG00000285044 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033210 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: solute carrier family 9".

[pmid12783626-6] Oduru S, Campbell JL, Karri S, Hendry WJ, Khan SA, Williams SC (June 2003). "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs". BMC Genomics. 4 (1): 22. doi:10.1186/1471-2164-4-22. PMC 161800 . PMID 12783626.

[pmid14634667-7] Wang D, King SM, Quill TA, Doolittle LK, Garbers DL (December 2003). "A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility". Nature Cell Biology. 5 (12): 1117–22. doi:10.1038/ncb1072. PMID 14634667. S2CID 12912080.

[1]

[2]

[3]

[4]

[5]

[6]

[7]