Sodium-coupled neutral amino acid transporter 2

SLC38A2
Identifiers
Aliases	SLC38A2 , ATA2, PRO1068, SAT2, SNAT2, solute carrier family 38 member 2
External IDs	OMIM: 605180 MGI: 1915010 HomoloGene: 23132 GeneCards: SLC38A2
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.11 Start 46,358,188 bp [1] End 46,372,773 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 F1 Start 96,585,273 bp [2] End 96,597,611 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia visceral pleura parietal pleura endothelial cell lower lobe of lung germinal epithelium cavity of mouth parotid gland superficial temporal artery Brodmann area 23 Top expressed in medullary collecting duct pineal gland renal corpuscle Paneth cell hand lacrimal gland atrium parotid gland olfactory epithelium calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding symporter activity amino acid transmembrane transporter activity L-glutamine transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane axon neuronal cell body dendrite brush border sarcolemma Biological process sodium ion transport female pregnancy cellular response to amino acid starvation glutamate secretion cellular response to mechanical stimulus glycine betaine transport cerebral cortex development amino acid transport alanine transport ion transport amino acid transmembrane transport glutamine transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54407 67760 Ensembl ENSG00000134294 ENSMUSG00000022462 UniProt Q96QD8 Q8CFE6 RefSeq (mRNA) NM_001307936 NM_018976 NM_175121 NM_001355633 RefSeq (protein) NP_001294865 NP_061849 NP_061849.2 NP_780330 NP_001342562 Location (UCSC) Chr 12: 46.36 – 46.37 Mb Chr 15: 96.59 – 96.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene. ^{[5] [6] [7]}

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000134294 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022462 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V (Jul 2000). "Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A". J Biol Chem. 275 (22): 16473–7. doi: 10.1074/jbc.C000205200 . PMID   10747860.
6. Zhang Z, Grewer C (Mar 2007). "The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates". Biophys J. 92 (7): 2621–32. Bibcode:2007BpJ....92.2621Z. doi:10.1529/biophysj.106.100776. PMC   1864845 . PMID   17237199.
7. "Entrez Gene: SLC38A2 solute carrier family 38, member 2".

Further reading

• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Hatanaka T, Huang W, Wang H, et al. (2000). "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.". Biochim. Biophys. Acta. 1467 (1): 1–6. doi:10.1016/S0005-2736(00)00252-2. PMID   10930503.
• Freeman TL, Thiele GM, Tuma DJ, et al. (2002). "ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane". Arch. Biochem. Biophys. 400 (2): 215–22. doi:10.1016/S0003-9861(02)00006-1. PMID   12054432.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Palii SS, Chen H, Kilberg MS (2004). "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element". J. Biol. Chem. 279 (5): 3463–71. doi: 10.1074/jbc.M310483200 . PMID   14623874.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Franchi-Gazzola R, Gaccioli F, Bevilacqua E, et al. (2005). "The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity". Biochim. Biophys. Acta. 1667 (2): 157–66. doi:10.1016/j.bbamem.2004.09.012. PMID   15581851.
• Bevilacqua E, Bussolati O, Dall'Asta V, et al. (2005). "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress". FEBS Lett. 579 (16): 3376–80. doi: 10.1016/j.febslet.2005.05.002 . PMID   15922329. S2CID   30690140.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID   15951569.
• Novak D, Quiggle F, Haafiz A (2006). "Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells". Biochimie. 88 (1): 39–44. doi:10.1016/j.biochi.2005.07.002. PMID   16125834.
• Palii SS, Thiaville MM, Pan YX, et al. (2006). "Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene". Biochem. J. 395 (3): 517–27. doi:10.1042/BJ20051867. PMC   1462688 . PMID   16445384.
• Melone M, Varoqui H, Erickson JD, Conti F (2006). "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex". Neuroscience. 140 (1): 281–92. doi:10.1016/j.neuroscience.2006.02.042. PMID   16616430. S2CID   10542427.
• Gaccioli F, Huang CC, Wang C, et al. (2006). "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation". J. Biol. Chem. 281 (26): 17929–40. doi: 10.1074/jbc.M600341200 . PMID   16621798.
• Jones HN, Ashworth CJ, Page KR, McArdle HJ (2006). "Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)". Am. J. Physiol. Endocrinol. Metab. 291 (3): E596–603. doi:10.1152/ajpendo.00359.2005. PMID   16621896. S2CID   11068094.