Sodium-dependent phosphate transport protein 1

SLC17A1
Identifiers
Aliases	SLC17A1 , NAPI-1, NPT-1, NPT1, solute carrier family 17 member 1
External IDs	OMIM: 182308 MGI: 103209 HomoloGene: 48324 GeneCards: SLC17A1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	25,832,052 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	24,079,713 bp
RNA expression pattern
	Top expressed in
	kidney; ; right lobe of liver; ; kidney tubule; ; renal cortex; ; metanephric glomerulus; ; renal medulla; ; islet of Langerhans; ; Left adrenal gland; ; middle temporal gyrus; ; Right adrenal gland;
	Top expressed in
	kidney; ; proximal tubule; ; left lobe of liver; ; retinal pigment epithelium; ; duodenum; ; jejunum; ; superior frontal gyrus; ; quadriceps femoris muscle; ; sexually immature organism; ; large intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium:phosphate symporter activity ; phosphate ion transmembrane transporter activity ; symporter activity ; sialic acid transmembrane transporter activity ;
Cellular component	integral component of membrane ; integral component of plasma membrane ; membrane ; plasma membrane ; apical plasma membrane ; lysosome ;
Biological process	phosphate ion transport ; phosphate ion transmembrane transport ; ion transport ; sodium ion transmembrane transport ; urate metabolic process ; sodium ion transport ; transmembrane transport ; sodium-dependent phosphate transport ; urate transport ; sialic acid transport ;
	Sources:Amigo / QuickGO
Orthologs
	6568
	20504
	ENSG00000124568
	ENSMUSG00000021335
	Q14916
	Q61983
	NM_005074
	NM_001170638 ; NM_009198
	NP_005065
	NP_001164109 ; NP_033224
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.^[5]^[6]

Related Research Articles

The sodium/phosphate cotransporter is a member of the phosphate:Na⁺ symporter (PNaS) family within the TOG Superfamily of transport proteins as specified in the Transporter Classification Database (TCDB).

Peptide transporter 1 also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.

Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a membrane transport protein that in humans is encoded by the SLC4A4 gene.

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene.

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.

Electrogenic sodium bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene.

Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124568 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021335 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chong SS, Kristjansson K, Zoghbi HY, Hughes MR (Feb 1994). "Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23". Genomics. 18 (2): 355–9. doi:10.1006/geno.1993.1476. PMID 8288239.
↑ "Entrez Gene: SLC17A1 solute carrier family 17 (sodium phosphate), member 1".

Miyamoto K, Tatsumi S, Sonoda T, et al. (1995). "Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression". Biochem. J. 305 (1): 81–5. doi:10.1042/bj3050081. PMC 1136432 . PMID 7826357.
Li H, Xie Z (1997). "Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts". Cell. Mol. Biol. Res. 41 (5): 451–60. PMID 8867793.
Taketani Y, Miyamoto K, Chikamori M, et al. (1998). "Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene". Biochim. Biophys. Acta. 1396 (3): 267–72. doi:10.1016/s0167-4781(97)00231-5. PMID 9545579.
Totaro A, Roetto A, Rommens JM, et al. (1998). "Generation of a transcription map of a 1 Mbase region containing the HFE gene (6p22)". Eur. J. Hum. Genet. 6 (2): 105–13. doi: 10.1038/sj.ejhg.5200162 . PMID 9781053.
Uchino H, Tamai I, Yamashita K, et al. (2000). "p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1". Biochem. Biophys. Res. Commun. 270 (1): 254–9. doi:10.1006/bbrc.2000.2407. PMID 10733936.
Soumounou Y, Gauthier C, Tenenhouse HS (2001). "Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity". Am. J. Physiol. Renal Physiol. 281 (6): F1082–91. doi:10.1152/ajprenal.0092.2001. PMID 11704559.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID 14531806.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124568 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021335 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8288239-5] Chong SS, Kristjansson K, Zoghbi HY, Hughes MR (Feb 1994). "Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23". Genomics. 18 (2): 355–9. doi:10.1006/geno.1993.1476. PMID 8288239.

[entrez-6] "Entrez Gene: SLC17A1 solute carrier family 17 (sodium phosphate), member 1".

[1]

[2]

[3]

[4]

[5]

[6]

Sodium-dependent phosphate transport protein 1

Contents

See also

Related Research Articles

References

Further reading