Sodium-dependent phosphate transport protein 2B

Last updated

SLC34A2
Identifiers
Aliases SLC34A2 , NAPI-3B, NAPI-IIb, NPTIIb, solute carrier family 34 member 2, PULAM
External IDs OMIM: 604217; MGI: 1342284; HomoloGene: 2297; GeneCards: SLC34A2; OMA:SLC34A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006424
NM_001177998
NM_001177999

NM_011402

RefSeq (protein)

NP_001171469
NP_001171470
NP_006415

NP_035532

Location (UCSC) Chr 4: 25.65 – 25.68 Mb Chr 5: 53.2 – 53.23 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene. [5] [6] [7]

Contents

Clinical significance

Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen. [8]

As of April 2023, upifitamab rilsodotin, an antibody-drug conjugate (ADC) targeting NaPi2b, is in Phase 3 clinical trials for recurrent platinum-sensitive ovarian cancer. [9]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000157765 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029188 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (May 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochemical and Biophysical Research Communications. 258 (3): 578–582. doi:10.1006/bbrc.1999.0666. PMID   10329428.
  6. Xu H, Bai L, Collins JF, Ghishan FK (December 1999). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics. 62 (2): 281–284. doi:10.1006/geno.1999.6009. PMID   10610722.
  7. "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".
  8. Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, et al. (February 2008). "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immunity. 8: 3. PMC   2935786 . PMID   18251464.
  9. Clinical trial number NCT05329545 for "Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer (UP-NEXT)." at ClinicalTrials.gov

Further reading