Sodium-dependent phosphate transport protein 2B

SLC34A2
Identifiers
Aliases	SLC34A2 , NAPI-3B, NAPI-IIb, NPTIIb, solute carrier family 34 member 2, PULAM
External IDs	OMIM: 604217 MGI: 1342284 HomoloGene: 2297 GeneCards: SLC34A2
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p15.2 Start 25,648,011 bp [1] End 25,678,748 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 C1|5 28.92 cM Start 53,195,423 bp [2] End 53,229,006 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung palpebral conjunctiva upper lobe of lung upper lobe of left lung bronchial epithelial cell right lung right uterine tube endometrium minor salivary gland right lobe of thyroid gland Top expressed in left lung left lung lobe right lung right lung lobe ileum jejunum spermatocyte spermatid corneal stroma morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphate ion binding sodium ion binding sodium:phosphate symporter activity symporter activity Cellular component integral component of membrane vesicle membrane plasma membrane integral component of plasma membrane brush border membrane apical plasma membrane brush border cytoplasm Biological process phosphate ion transport sodium-dependent phosphate transport sodium ion transport cellular phosphate ion homeostasis in utero embryonic development response to estrogen phosphate ion transmembrane transport sodium ion transmembrane transport ion transport transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10568 20531 Ensembl ENSG00000157765 ENSMUSG00000029188 UniProt O95436 Q9DBP0 RefSeq (mRNA) NM_006424 NM_001177998 NM_001177999 NM_011402 RefSeq (protein) NP_001171469 NP_001171470 NP_006415 NP_035532 Location (UCSC) Chr 4: 25.65 – 25.68 Mb Chr 5: 53.2 – 53.23 Mb PubMed search [3] [4]
Wikidata
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Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene. ^{[5] [6] [7]}

Clinical significance

Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen. ^[8]

See also

• Solute carrier family
• Pulmonary alveolar microlithiasis

References

1. GRCh38: Ensembl release 89: ENSG00000157765 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029188 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (Jun 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochem Biophys Res Commun. 258 (3): 578–82. doi:10.1006/bbrc.1999.0666. PMID   10329428.
6. Xu H, Bai L, Collins JF, Ghishan FK (Feb 2000). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics. 62 (2): 281–4. doi:10.1006/geno.1999.6009. PMID   10610722.
7. "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".
8. Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, Bhaskaran N, Souchelnytskyi S, Hellman U, Filonenko V, Jungbluth AA, Odunsi K, Lloyd KO, Old LJ, Ritter G (2008). "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immun. 8: 3. PMC   2935786 . PMID   18251464.

Further reading

• Xu H, Collins JF, Bai L, et al. (2001). "Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor". Am. J. Physiol., Cell Physiol. 280 (3): C628–36. doi:10.1152/ajpcell.2001.280.3.C628. PMID   11171583. S2CID   7439508.
• Segawa H, Kaneko I, Takahashi A, et al. (2002). "Growth-related renal type II Na/Pi cotransporter". J. Biol. Chem. 277 (22): 19665–72. doi: 10.1074/jbc.M200943200 . PMID   11880379.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Xu H, Uno JK, Inouye M, et al. (2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G175–81. doi:10.1152/ajpgi.00396.2004. PMID   15458926. S2CID   14194207.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Corut A, Senyigit A, Ugur SA, et al. (2006). "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis". Am. J. Hum. Genet. 79 (4): 650–6. doi:10.1086/508263. PMC   1592565 . PMID   16960801.
• Huqun, Izumi S, Miyazawa H, et al. (2007). "Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis". Am. J. Respir. Crit. Care Med. 175 (3): 263–8. doi:10.1164/rccm.200609-1274OC. PMID   17095743.