Sodium bicarbonate cotransporter 3

SLC4A7
Identifiers
Aliases	SLC4A7 , NBC2, NBC3, NBCN1, SBC2, SLC4A6, solute carrier family 4 member 7
External IDs	OMIM: 603353; MGI: 2443878; HomoloGene: 2680; GeneCards: SLC4A7; OMA:SLC4A7 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p24.1 Start 27,372,721 bp [1] End 27,484,420 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A1 Start 14,702,279 bp [2] End 14,799,940 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte duodenum Achilles tendon jejunal mucosa secondary oocyte lactiferous duct sural nerve frontal pole paraflocculus of cerebellum Brodmann area 23 Top expressed in duodenum left colon retina olfactory epithelium neural layer of retina medial ganglionic eminence islet of Langerhans uterus soleus muscle spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inorganic anion exchanger activity symporter activity anion transmembrane transporter activity sodium:bicarbonate symporter activity protein binding Cellular component integral component of membrane cell projection membrane plasma membrane synapse stereocilium basolateral plasma membrane apical plasma membrane cytoplasmic vesicle integral component of plasma membrane Biological process sodium ion transport anion transport auditory receptor cell development ion transport inorganic anion transport regulation of intracellular pH bicarbonate transport transmembrane transport anion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9497 218756 Ensembl ENSG00000033867 ENSMUSG00000021733 UniProt Q9Y6M7 Q8BTY2 RefSeq (mRNA) NM_001258379 NM_001258380 NM_003615 NM_001321103 NM_001321104 NM_001321105 NM_001321106 NM_001321107 NM_001321108 NM_001033270 RefSeq (protein) NP_001245308 NP_001245309 NP_001308032 NP_001308033 NP_001308034 NP_001308035 NP_001308036 NP_001308037 NP_003606 n/a Location (UCSC) Chr 3: 27.37 – 27.48 Mb Chr 14: 14.7 – 14.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene. ^[5]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000033867 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021733 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7".

Further reading

• Ishibashi K, Sasaki S, Marumo F (1998). "Molecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina". Biochem. Biophys. Res. Commun. 246 (2): 535–8. doi:10.1006/bbrc.1998.8658. PMID   9610397.
• Pushkin A, Abuladze N, Lee I, et al. (1999). "Mapping of the human NBC3 (SLC4A7) gene to chromosome 3p22". Genomics. 57 (2): 321–2. doi:10.1006/geno.1999.5781. PMID   10198178.
• Pushkin A, Abuladze N, Lee I, et al. (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi: 10.1074/jbc.274.23.16569 . PMID   10347222.
• Pushkin A, Yip KP, Clark I, et al. (2000). "NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase". Am. J. Physiol. 277 (6 Pt 2): F974–81. doi:10.1152/ajprenal.1999.277.6.F974. PMID   10600945. S2CID   4457223.
• Park M, Ko SB, Choi JY, et al. (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi: 10.1074/jbc.M201862200 . PMID   12403779.
• Loiselle FB, Jaschke P, Casey JR (2004). "Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain". Mol. Membr. Biol. 20 (4): 307–17. doi:10.1080/0968768031000122520. PMID   14578046. S2CID   30980041.
• Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID   14736710. S2CID   16522705.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Reiners J, van Wijk E, Märker T, et al. (2006). "Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2". Hum. Mol. Genet. 14 (24): 3933–43. doi: 10.1093/hmg/ddi417 . PMID   16301216.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.