Sodium bicarbonate cotransporter 3

SLC4A7
Identifiers
Aliases	SLC4A7 , NBC2, NBC3, NBCN1, SBC2, SLC4A6, solute carrier family 4 member 7
External IDs	OMIM: 603353 MGI: 2443878 HomoloGene: 2680 GeneCards: SLC4A7
Gene location (Human)
Chr.	Chromosome 3 (human)
End	27,484,420 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	14,799,940 bp
RNA expression pattern
	Top expressed in
	oocyte; ; duodenum; ; Achilles tendon; ; jejunal mucosa; ; secondary oocyte; ; lactiferous duct; ; sural nerve; ; frontal pole; ; Brodmann area 23; ; superficial temporal artery;
	Top expressed in
	duodenum; ; left colon; ; retina; ; olfactory epithelium; ; medial ganglionic eminence; ; islet of Langerhans; ; uterus; ; soleus muscle; ; spermatid; ; subiculum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	inorganic anion exchanger activity ; symporter activity ; anion transmembrane transporter activity ; sodium:bicarbonate symporter activity ; protein binding ;
Cellular component	integral component of membrane ; cell projection ; membrane ; plasma membrane ; synapse ; stereocilium ; basolateral plasma membrane ; apical plasma membrane ; cytoplasmic vesicle ; integral component of plasma membrane ;
Biological process	sodium ion transport ; anion transport ; auditory receptor cell development ; ion transport ; inorganic anion transport ; regulation of intracellular pH ; bicarbonate transport ; transmembrane transport ; anion transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	9497
	218756
	ENSG00000033867
	ENSMUSG00000021733
	Q9Y6M7
	Q8BTY2
NM_001258379 ; NM_001258380 ; NM_003615 ; NM_001321103 ; NM_001321104 ;
	NM_001321105 ; NM_001321106 ; NM_001321107 ; NM_001321108 Contents See also ; References ; Further reading ;
	NM_001033270
NP_001245308 ; NP_001245309 ; NP_001308032 ; NP_001308033 ; NP_001308034 ;
	NP_001308035 ; NP_001308036 ; NP_001308037 ; NP_003606
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 26, 2023

Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene.^[5]

Related Research Articles

Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed to interact via long-range allostery, involving significant protein dynamics.

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.

Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a membrane transport protein that in humans is encoded by the SLC4A4 gene.

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.

Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene.

Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl⁻/HCO3⁻ exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have been linked to seizures.

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.

Sodium bicarbonate transporter-like protein 11 is a protein that in humans is encoded by the SLC4A11 gene.

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

<span class="mw-page-title-main">Electroneutral sodium bicarbonate exchanger 1</span> Protein-coding gene in the species Homo sapiens

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.

Solute carrier family 12 member 6 is a protein that in humans is encoded by the SLC12A6 gene.

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Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the SLC51A gene.

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Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.

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The anion exchanger family is a member of the large APC superfamily of secondary carriers. Members of the AE family are generally responsible for the transport of anions across cellular barriers, although their functions may vary. All of them exchange bicarbonate. Characterized protein members of the AE family are found in plants, animals, insects and yeast. Uncharacterized AE homologues may be present in bacteria. Animal AE proteins consist of homodimeric complexes of integral membrane proteins that vary in size from about 900 amino acyl residues to about 1250 residues. Their N-terminal hydrophilic domains may interact with cytoskeletal proteins and therefore play a cell structural role. Some of the currently characterized members of the AE family can be found in the Transporter Classification Database.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000033867 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021733 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7".

Ishibashi K, Sasaki S, Marumo F (1998). "Molecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina". Biochem. Biophys. Res. Commun. 246 (2): 535–8. doi:10.1006/bbrc.1998.8658. PMID 9610397.
Pushkin A, Abuladze N, Lee I, et al. (1999). "Mapping of the human NBC3 (SLC4A7) gene to chromosome 3p22". Genomics. 57 (2): 321–2. doi:10.1006/geno.1999.5781. PMID 10198178.
Pushkin A, Abuladze N, Lee I, et al. (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi: 10.1074/jbc.274.23.16569 . PMID 10347222.
Pushkin A, Yip KP, Clark I, et al. (2000). "NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase". Am. J. Physiol. 277 (6 Pt 2): F974–81. doi:10.1152/ajprenal.1999.277.6.F974. PMID 10600945.
Park M, Ko SB, Choi JY, et al. (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi: 10.1074/jbc.M201862200 . PMID 12403779.
Loiselle FB, Jaschke P, Casey JR (2004). "Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain". Mol. Membr. Biol. 20 (4): 307–17. doi:10.1080/0968768031000122520. PMID 14578046. S2CID 30980041.
Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710. S2CID 16522705.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Reiners J, van Wijk E, Märker T, et al. (2006). "Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2". Hum. Mol. Genet. 14 (24): 3933–43. doi: 10.1093/hmg/ddi417 . PMID 16301216.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000033867 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021733 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7".

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Sodium bicarbonate cotransporter 3

Contents

See also

Related Research Articles

References

Further reading