Solute carrier organic anion transporter family member 1A2

SLCO1A2
Identifiers
Aliases	SLCO1A2 , OATP, OATP-A, OATP1A2, SLC21A3, solute carrier organic anion transporter family member 1A2
External IDs	OMIM: 602883 MGI: 1351865 HomoloGene: 56603 GeneCards: SLCO1A2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,419,594 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,268,707 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; amygdala; ; optic nerve; ; putamen; ; substantia nigra; ; hypothalamus; ; caudate nucleus; ; hippocampus proper; ; Brodmann area 9; ; nucleus accumbens;
	Top expressed in
	seminal vesicula; ; stria vascularis; ; salivary gland; ; choroid plexus; ; olfactory epithelium; ; submandibular gland; ; lacrimal gland; ; parotid gland; ; morula; ; secondary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity ; organic anion transmembrane transporter activity ; bile acid transmembrane transporter activity ; sodium-independent organic anion transmembrane transporter activity ;
Cellular component	integral component of membrane ; membrane ; plasma membrane ; integral component of plasma membrane ;
Biological process	ion transport ; organic anion transport ; bile acid and bile salt transport ; sodium-independent organic anion transport ; transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	6579
	108096
	ENSG00000084453
	ENSMUSG00000063975
	P46721
	Q91YY5
	NM_005075 ; NM_021094 ; NM_134431
	NM_001267707 ; NM_130861
	NP_066580 ; NP_602307
	NP_001254636 ; NP_570931
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 01, 2024

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.^[5]^[6]

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.^[6]

Related Research Articles

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

Sodium/bile acid cotransporter also known as the Na⁺-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the SLC51A gene.

Solute carrier organic anion transporter family member 4A1 is a protein that in humans is encoded by the SLCO4A1 gene.

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.

Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

Solute carrier family 22 member 10 (SLC22A10), also known as organic anion transporter 5 (OAT5), is a protein that in humans is encoded by the SLC22A10 gene.

Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.

Members of the organic solute transporter (OST) family have been characterized from a small bottom feeding species of fish called the little skate, Raja erinacea. Members have also been characterized from humans and mice. The OST family is a member of the larger group of secondary carriers, the APC superfamily.

Solute carrier organic anion transporter family member 4C1 is a protein that in humans is encoded by the SLCO4C1 gene, which is located on chromosome 5q21. The OATP4C1 protein is expressed in the basolateral membrane of the nephron of the human kidney, where it is involved in the uptake of organic anions for elimination in the urine. The drug digoxin is an important substrate of this transporter.

Members of the Organo Anion Transporter (OAT) Family are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer of the cell membrane, acting as the cell's gatekeepers. OATPs belong to the Solute Carrier Family (SLC) and the major facilitator superfamily.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000084453 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063975 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol. 25 (6): 985–7. doi:10.1016/S0168-8278(96)80307-2. PMID 9007731.
1 2 "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2".

Meier PJ, Eckhardt U, Schroeder A, et al. (1998). "Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver". Hepatology. 26 (6): 1667–77. doi:10.1002/hep.510260641. PMID 9398014. S2CID 20039812.
Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. (1995). "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver". Gastroenterology. 109 (4): 1274–82. doi:10.1016/0016-5085(95)90588-X. PMID 7557095.
Kullak-Ublick GA, Beuers U, Fahney C, et al. (1997). "Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene". Hepatology. 26 (4): 991–7. doi:10.1002/hep.510260429. PMID 9328325. S2CID 43606355.
Kullak-Ublick GA, Fisch T, Oswald M, et al. (1998). "Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain". FEBS Lett. 424 (3): 173–6. doi: 10.1016/S0014-5793(98)00168-9 . PMID 9539145. S2CID 21231745.
König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi: 10.1074/jbc.M001448200 . PMID 10779507.
Tamai I, Nezu J, Uchino H, et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
Speek M (2001). "Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790 . PMID 11238933.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Lee W, Glaeser H, Smith LH, et al. (2005). "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry". J. Biol. Chem. 280 (10): 9610–7. doi: 10.1074/jbc.M411092200 . PMID 15632119.
Su Y, Zhang X, Sinko PJ (2005). "Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells". Mol. Pharm. 1 (1): 49–56. doi:10.1021/mp0340136. PMID 15832500.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000084453 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063975 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9007731-5] Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol. 25 (6): 985–7. doi:10.1016/S0168-8278(96)80307-2. PMID 9007731.

[entrez-6] 1 2 "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2".

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Solute carrier organic anion transporter family member 1A2

Contents

See also

Related Research Articles

References

Further reading