Tombozine

Tombozine

Identifiers
CAS Number	604-99-9  Y
3D model (JSmol)	Interactive image
ChemSpider	28424456
PubChem CID	5460176
UNII	8RD788YSD2  Y
InChI InChI=1S/C19H22N2O/c1-2-11-9-21-17-8-14-12-5-3-4-6-16(12)20-19(14)18(21)7-13(11)15(17)10-22/h2-6,13,15,17-18,20,22H,7-10H2,1H3/b11-2-/t13-,15?,17-,18-/m0/s1 Key: VXTDUGOBAOLMED-GJKVQYCKSA-N
SMILES C/C=C\1/CN2[C@H]3C[C@@H]1C([C@@H]2CC4=C3NC5=CC=CC=C45)CO
Properties
Chemical formula	C19H22N2O
Molar mass	294.398 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Tombozine is an alkaloid found in the plant species Vinca minor . The chemical has been found to have a sedative effect in mice and to lower blood pressure in some domesticated animals. ^[1]

Ref: ^{[2] [3] [4] [5] [6] [7]}

References

1. Neuwinger, Hans Dieter (1996). African Ethnobotany: Poisons and Drugs : Chemistry, Pharmacology, Toxicology. CRC Press. p. 135. ISBN   9783826100772.
2. Battersby, A. R., Binks, R., Hodson, H. F., Yeowell, D. A. (1960). "368. Alkaloids of calabash-curare and Strychnos species. Part II. Isolation of new alkaloids". Journal of the Chemical Society (Resumed): 1848. doi:10.1039/jr9600001848.
3. Battersby, Yeowell., Proc. Chem. Soc., 17 (1961) https://doi.org/10.1039/PS9610000001
4. Stauffacher., Helv. Chim. Acta, 44, 2006 (1961). https://onlinelibrary.wiley.com/doi/abs/10.1002/hlca.19610440725
5. Levy, LeMen, Janot., Compt. Rend., 253, 131 (1961).
6. Rapoport, Moore.,J. Org. Chem., 27, 2981 (1962). https://pubs.acs.org/doi/pdf/10.1021/jo01056a004
7. Antonaccio et al., J. Amer. Chem. Soc., 84, 2161 (1962). https://pubs.acs.org/doi/pdf/10.1021/ja00870a030