Urea transporter 2

SLC14A2
Identifiers
Aliases	SLC14A2 , HUT2, UT-A2, UT2, UTA, UTR, hUT-A6, solute carrier family 14 member 2
External IDs	OMIM: 601611 MGI: 1351653 HomoloGene: 5183 GeneCards: SLC14A2
Gene location (Human)
Chr.	Chromosome 18 (human)
End	45,683,688 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	78,640,157 bp
RNA expression pattern
	Top expressed in
	Right adrenal gland; ; Left adrenal gland; ; Achilles tendon; ; kidney; ; appendix; ; subcutaneous adipose tissue; ; ganglionic eminence; ; right lung; ; right coronary artery; ; left coronary artery;
	Top expressed in
	inner renal medulla; ; respiratory epithelium; ; olfactory epithelium; ; thin ascending limb of loop of Henle; ; kidney; ; inner stripe of outer renal medulla; ; seminiferous tubule; ; pretectal area; ; proximal convoluted tubule; ; right ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	urea transmembrane transporter activity ; cell adhesion molecule binding ; protein binding ; urea channel activity ;
Cellular component	apical plasma membrane ; plasma membrane ; membrane ; integral component of membrane ; integral component of plasma membrane ;
Biological process	urea transmembrane transport ; transmembrane transport ; urea transport ;
	Sources:Amigo / QuickGO
Orthologs
	8170
	27411
	ENSG00000132874
	ENSMUSG00000024552
	Q15849
	Q8R4T9
	NM_001242692 ; NM_007163 ; NM_001371319
	NM_001110273 ; NM_001110274 ; NM_030683 ; NM_207651
	NP_001229621 ; NP_009094 ; NP_001358248
	NP_001103743 ; NP_001103744 ; NP_109608 ; NP_997534
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene.^[5]^[6]

Function

In mammalian cells, urea is the chief end-product of nitrogen catabolism and plays an important role in the urinary concentration mechanism. Thus, the plasma membrane of erythrocytes and some renal epithelial cells exhibit an elevated urea permeability that is mediated by highly selective urea transporters. In mammals, two urea transporters have been identified: the renal tubular urea transporter, UT2 (UT-A), and the erythrocyte urea transporter, UT11 (also called UT-B, coded for by the SLC14A1 gene).^[6] SLC14A2 and SLC14A1 constitute solute carrier family 14.

Related Research Articles

Thiamine transporter 2 (ThTr-2), also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene. SLC19A3 is a thiamine transporter.

A urea transporter is a membrane transport protein, transporting urea. Humans and other mammals have two types of urea transport proteins, UT-A and UT-B. The UT-A proteins are important for renal urea handling and are produced by alternative splicing of the SLC14A2 gene. Urea transport in the kidney is regulated by vasopressin.

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

Aquaporin-9 (AQP-9) is a protein that in humans is encoded by the AQP9 gene.

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.

Solute carrier family 12 member 6 is a protein that in humans is encoded by the SLC12A6 gene.

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132874 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024552 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P (Jul 1996). "Molecular characterization of a new urea transporter in the human kidney" (PDF). FEBS Lett. 386 (2–3): 156–60. doi:10.1016/0014-5793(96)00425-5. PMID 8647271. S2CID 13312002.
1 2 "Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2".

Smith CP, Fenton RA (2007). "Genomic organization of the mammalian SLC14a2 urea transporter genes". J. Membr. Biol. 212 (2): 109–17. doi:10.1007/s00232-006-0870-z. PMID 17264986. S2CID 12514783.
Olives B, Neau P, Bailly P, et al. (1995). "Cloning and functional expression of a urea transporter from human bone marrow cells". J. Biol. Chem. 269 (50): 31649–52. doi: 10.1016/S0021-9258(18)31744-7 . PMID 7989337.
Bradford AD, Terris JM, Ecelbarger CA, et al. (2001). "97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation". Am. J. Physiol. Renal Physiol. 281 (1): F133–43. doi:10.1152/ajprenal.2001.281.1.F133. PMID 11399654. S2CID 393209.
Bagnasco SM, Peng T, Janech MG, et al. (2001). "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene". Am. J. Physiol. Renal Physiol. 281 (3): F400–6. doi:10.1152/ajprenal.2001.281.3.F400. PMID 11502588. S2CID 17458312.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Jung JY, Madsen KM, Han KH, et al. (2003). "Expression of urea transporters in potassium-depleted mouse kidney". Am. J. Physiol. Renal Physiol. 285 (6): F1210–24. doi:10.1152/ajprenal.00111.2003. PMID 12952854.
Smith CP, Potter EA, Fenton RA, Stewart GS (2004). "Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6". Am. J. Physiol., Cell Physiol. 287 (4): C1087–93. doi:10.1152/ajpcell.00363.2003. PMID 15189812. S2CID 26010752.
Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas". Placenta. 27 (11–12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.
Hong X, Xing H, Yu Y, et al. (2007). "Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS". Methods and Findings in Experimental and Clinical Pharmacology. 29 (1): 3–10. doi:10.1358/mf.2007.29.1.1063490. PMID 17344938.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132874 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024552 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8647271-5] Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P (Jul 1996). "Molecular characterization of a new urea transporter in the human kidney" (PDF). FEBS Lett. 386 (2–3): 156–60. doi:10.1016/0014-5793(96)00425-5. PMID 8647271. S2CID 13312002.

[entrez-6] 1 2 "Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2".

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Urea transporter 2

Contents

Function

Related Research Articles

References

Further reading