Zinc transporter 4

SLC30A4
Identifiers
Aliases	SLC30A4 , ZNT4, znT-4, solute carrier family 30 member 4
External IDs	OMIM: 602095 MGI: 1345282 HomoloGene: 74984 GeneCards: SLC30A4
Gene location (Human)
Chr.	Chromosome 15 (human)
End	45,522,755 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	122,544,583 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; Brodmann area 23; ; middle temporal gyrus; ; oocyte; ; secondary oocyte; ; germinal epithelium; ; endothelial cell; ; external globus pallidus; ; synovial joint; ; trigeminal ganglion;
	Top expressed in
	jejunum; ; ileum; ; uterus; ; placenta; ; spermatid; ; secondary oocyte; ; testicle; ; colon; ; spermatocyte; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cation transmembrane transporter activity ; zinc ion transmembrane transporter activity ; protein binding ;
Cellular component	cytoplasm ; integral component of membrane ; endosome ; late endosome ; membrane ; late endosome membrane ; lysosomal membrane ; lysosome ; endosome membrane ; plasma membrane ;
Biological process	zinc ion homeostasis ; zinc ion transport ; response to zinc ion ; cation transport ; ion transport ; cation transmembrane transport ; transmembrane transport ; regulation of sequestering of zinc ion ; response to toxic substance ; zinc ion transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	7782
	22785
	ENSG00000104154
	ENSMUSG00000005802
	O14863
	O35149
	NM_013309 ; NM_001321036
	NM_001290993 ; NM_011774
	NP_001307965 ; NP_037441
	NP_001277922 ; NP_035904
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 28, 2023

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.^[5]

Related Research Articles

<span class="mw-page-title-main">Acrodermatitis enteropathica</span> Medical condition

Acrodermatitis enteropathica is an autosomal recessive metabolic disorder affecting the uptake of zinc through the inner lining of the bowel, the mucous membrane. It is characterized by inflammation of the skin (dermatitis) around bodily openings (periorificial) and the tips of fingers and toes (acral), hair loss (alopecia), and diarrhea. It can also be related to deficiency of zinc due to other, i.e. congenital causes.

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.

Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. In particular, ZNT8 is critical for the accumulation of zinc into beta cell secretory granules and the maintenance of stored insulin as tightly-packaged hexamers. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.

Zinc transporter ZIP4 is a transmembrane protein which in humans is encoded by the SLC39A4 gene. It is associated with acrodermatitis enteropathica.

Thiamine transporter 2 (ThTr-2), also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene. SLC19A3 is a thiamine transporter.

Glucose-6-phosphate exchanger SLC37A4, also known as glucose-6-phosphate translocase, is an enzyme that in humans is encoded by the SLC37A4 gene.

Sialin, also known as H(+)/nitrate cotransporter and H(+)/sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene.

Sodium- and chloride-dependent creatine transporter 1 is a protein that in humans is encoded by the SLC6A8 gene.

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.

Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene.

Y+L amino acid transporter 1 is a protein that in humans is encoded by the SLC7A7 gene.

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.

Zinc transporter 7 is a protein that in humans is encoded by the SLC30A7 gene.

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.

Zinc transporter ZIP10, also known as solute carrier family 39 member 10, is a protein that in humans is encoded by the SLC39A10 gene. ZIP10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters, and have 14 members in the human genome: ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7, ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13 and ZIP14.

Zinc transporter ZIP9, also known as Zrt- and Irt-like protein 9 (ZIP9) and solute carrier family 39 member 9, is a protein that in humans is encoded by the SLC39A9 gene. This protein is the 9th member out of 14 ZIP family proteins, which is a membrane androgen receptor (mAR) coupled to G proteins, and also classified as a zinc transporter protein. ZIP family proteins transport zinc metal from the extracellular environment into cells through cell membrane.

Solute carrier family 39 member 12 is a protein that in humans is encoded by the SLC39A12 gene.

Solute carrier family 30 member 10 is a protein that in humans is encoded by the SLC30A10 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104154 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005802 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4".

Huang L, Gitschier J (1997). "A novel gene involved in zinc transport is deficient in the lethal milk mouse". Nat. Genet. 17 (3): 292–7. doi:10.1038/ng1197-292. PMID 9354792. S2CID 8000689.
Murgia C, Vespignani I, Cerase J, et al. (2000). "Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells". Am. J. Physiol. 277 (6 Pt 1): G1231–9. doi:10.1152/ajpgi.1999.277.6.G1231. PMID 10600821. S2CID 31257828.
Küry S, Devilder MC, Avet-Loiseau H, et al. (2001). "Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica". Hum. Genet. 109 (2): 178–85. doi:10.1007/s004390100539. PMID 11511923. S2CID 11501283.
Bleck O, Ashton GH, Mallipeddi R, et al. (2002). "Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica". Arch. Dermatol. Res. 293 (8): 392–6. doi:10.1007/s004030100246. PMID 11686514. S2CID 13027648.
Nakano A, Nakano H, Hanada K, et al. (2002). "ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families". Hum. Genet. 110 (2): 201–2. doi:10.1007/s00439-001-0661-7. PMID 11935329. S2CID 37006354.
Michalczyk AA, Allen J, Blomeley RC, Ackland ML (2002). "Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells". Biochem. J. 364 (Pt 1): 105–13. doi:10.1042/bj3640105. PMC 1222551 . PMID 11988082.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Michalczyk A, Varigos G, Catto-Smith A, et al. (2003). "Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk". Hum. Genet. 113 (3): 202–10. doi:10.1007/s00439-003-0952-2. PMID 12743795. S2CID 36141272.
Henshall SM, Afar DE, Rasiah KK, et al. (2003). "Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer". Oncogene. 22 (38): 6005–12. doi: 10.1038/sj.onc.1206797 . PMID 12955079.
Beck FW, Prasad AS, Butler CE, et al. (2004). "Differential expression of hZnT-4 in human prostate tissues". Prostate. 58 (4): 374–81. doi:10.1002/pros.10344. PMID 14968438. S2CID 24889031.
Ho LH, Ruffin RE, Murgia C, et al. (2004). "Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation". J. Immunol. 172 (12): 7750–60. doi: 10.4049/jimmunol.172.12.7750 . PMID 15187159.
Smith JL, Xiong S, Markesbery WR, Lovell MA (2006). "Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain". Neuroscience. 140 (3): 879–88. doi:10.1016/j.neuroscience.2006.02.049. PMID 16580781. S2CID 29807730.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104154 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005802 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4".

[1]

[2]

[3]

[4]

[5]

Zinc transporter 4

Contents

See also

Related Research Articles

References

Further reading