Zinc transporter 7

SLC30A7
Identifiers
Aliases	SLC30A7 , ZNT7, ZnT-7, ZnTL2, solute carrier family 30 member 7
External IDs	OMIM: 611149 MGI: 1913750 HomoloGene: 11332 GeneCards: SLC30A7
Gene location (Human)
Chr.	Chromosome 1 (human)
End	100,981,757 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	115,801,055 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; tibia; ; visceral pleura; ; jejunal mucosa; ; thymus; ; pylorus; ; superficial temporal artery; ; placenta; ; nipple; ; corpus epididymis;
	Top expressed in
	lacrimal gland; ; seminal vesicula; ; ectoderm; ; saccule; ; Paneth cell; ; otic placode; ; medullary collecting duct; ; salivary gland; ; submandibular gland; ; mucosa of urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	cation transmembrane transporter activity ; zinc ion transmembrane transporter activity ;
Cellular component	cytoplasm ; integral component of membrane ; perinuclear region of cytoplasm ; vesicle ; Golgi apparatus ; membrane ; cytoplasmic vesicle ;
Biological process	sequestering of zinc ion ; regulation of sequestering of zinc ion ; response to zinc ion ; cation transport ; zinc ion transport ; ion transport ; cation transmembrane transport ; zinc ion transmembrane transport ; transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	148867
	66500
	ENSG00000162695
	ENSMUSG00000054414
	Q8NEW0
	Q9JKN1
	NM_001144884 ; NM_133496
	NM_023214
	NP_001138356 ; NP_598003
	NP_075703
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 28, 2023

Zinc transporter 7 is a protein that in humans is encoded by the SLC30A7 gene.^[5]^[6]

Related Research Articles

Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. In particular, ZNT8 is critical for the accumulation of zinc into beta cell secretory granules and the maintenance of stored insulin as tightly-packaged hexamers. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.

Protein FAM107A is a protein that in humans is encoded by the FAM107A gene.

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.

Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.

60S ribosomal protein L36 is a protein that in humans is encoded by the RPL36 gene.

Cell growth-regulating nucleolar protein is a protein that in humans is encoded by the LYAR gene.

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.

Actin-binding Rho-activating protein is a protein that in humans is encoded by the ABRA gene. The mouse and rat homologues are known as STARS and MS1 respectively.

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.

Zinc finger CCHC domain-containing protein 2 is a protein that in humans is encoded by the ZCCHC2 gene.

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.

Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene.

E3 ubiquitin-protein ligase ZNRF1 is an enzyme that in humans is encoded by the ZNRF1 gene.

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

Zinc finger protein 571 is a protein that in humans is encoded by the ZNF571 gene.

Solute carrier family 25 member 39 is a protein that in humans is encoded by the SLC25A39 gene. The protein has been shown to be necessary for the import of the major antioxidant glutathione into the mitochondria.

Vasculin is a protein that in humans is encoded by the GPBP1 gene.

P3 protein is a protein that in humans is encoded by the SLC10A3 gene.

Tetratricopeptide repeat protein 25 is a protein that in humans is encoded by the TTC25 gene.

Sodium/bile acid cotransporter 7 is a protein which in humans is encoded by the SLC10A7 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162695 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054414 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kirschke CP, Huang L (Feb 2003). "ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus". J Biol Chem. 278 (6): 4096–102. doi: 10.1074/jbc.M207644200 . PMID 12446736.
↑ "Entrez Gene: SLC30A7 solute carrier family 30 (zinc transporter), member 7".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Devergnas S, Chimienti F, Naud N, et al. (2004). "Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study". Biochem. Pharmacol. 68 (4): 699–709. doi:10.1016/j.bcp.2004.05.024. PMID 15276077.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162695 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054414 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12446736-5] Kirschke CP, Huang L (Feb 2003). "ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus". J Biol Chem. 278 (6): 4096–102. doi: 10.1074/jbc.M207644200 . PMID 12446736.

[entrez-6] "Entrez Gene: SLC30A7 solute carrier family 30 (zinc transporter), member 7".

[1]

[2]

[3]

[4]

[5]

[6]

Zinc transporter 7

Contents

See also

Related Research Articles

References

Further reading