Zinc transporter ZIP1

SLC39A1
Identifiers
Aliases	SLC39A1 , ZIP1, ZIRTL, solute carrier family 39 member 1
External IDs	OMIM: 604740 MGI: 1353474 HomoloGene: 40906 GeneCards: SLC39A1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 153,959,099 bp [1] End 153,968,184 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 90,155,479 bp [2] End 90,160,919 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta Achilles tendon upper lobe of left lung right lung stromal cell of endometrium gallbladder right adrenal gland left adrenal gland ascending aorta right coronary artery Top expressed in prostate belly cord epidermis lip uterus placenta urinary bladder gallbladder duodenum stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion transmembrane transporter activity inorganic cation transmembrane transporter activity zinc ion transmembrane transporter activity signaling receptor binding Cellular component integral component of membrane plasma membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process embryonic cranial skeleton morphogenesis metal ion transport zinc ion transmembrane transport cation transport zinc ion transport in utero embryonic development ion transport limb development transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27173 30791 Ensembl ENSG00000143570 ENSMUSG00000052310 UniProt Q9NY26 Q9QZ03 RefSeq (mRNA) NM_014437 NM_001271957 NM_001271958 NM_001271959 NM_001271960 NM_001271961 NM_013901 RefSeq (protein) NP_001258886 NP_001258887 NP_001258888 NP_001258889 NP_001258890 NP_055252 NP_038929 Location (UCSC) Chr 1: 153.96 – 153.97 Mb Chr 3: 90.16 – 90.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene. ^{[5] [6] [7]}

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc. ^[8]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000143570 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052310 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID   10610721.
6. Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi: 10.1074/jbc.275.8.5560 . PMID   10681536.
7. "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
8. Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi: 10.1186/1476-4598-5-17 . PMC   1481516 . PMID   16700911.

Further reading

• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
• Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells". J. Biol. Chem. 276 (25): 22258–64. doi: 10.1074/jbc.M101772200 . PMID   11301334.
• Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID   11696349. S2CID   19962909.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Franklin RB, Ma J, Zou J, et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells". J. Inorg. Biochem. 96 (2–3): 435–42. doi:10.1016/S0162-0134(03)00249-6. PMC   4465841 . PMID   12888280.
• Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi: 10.1074/jbc.M304163200 . PMID   14525987.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Franklin RB, Feng P, Milon B, et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer. 4: 32. doi: 10.1186/1476-4598-4-32 . PMC   1243239 . PMID   16153295.
• Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone. 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID   16203195.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi: 10.1111/j.1742-4658.2007.05933.x . PMID   17635580. S2CID   21792127.