Zinc transporter ZIP2

SLC39A2
Identifiers
Aliases	SLC39A2 , 6A1, ETI-1, ZIP-2, ZIP2, solute carrier family 39 member 2
External IDs	OMIM: 612166 MGI: 2684326 HomoloGene: 40957 GeneCards: SLC39A2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	21,001,871 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	52,134,202 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; epithelium of esophagus; ; vulva; ; cervix epithelium; ; seminal vesicula; ; vagina; ; palpebral conjunctiva; ; sperm; ; cavity of mouth; ; human penis;
	Top expressed in
	cervix; ; lip; ; olfactory epithelium; ; morula; ; superior frontal gyrus; ; cerebellar cortex; ; skin of abdomen; ; esophagus; ; skin of back; ; olfactory bulb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion transmembrane transporter activity ; zinc ion transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ; cytoplasmic vesicle ;
Biological process	metal ion transport ; zinc ion transport ; ion transport ; zinc ion transmembrane transport ; transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	29986
	214922
	ENSG00000165794
	ENSMUSG00000072572
	Q9NP94
	G3X943
	NM_014579 ; NM_001256588
	NM_001039676
	NP_001243517 ; NP_055394
	NP_001034765
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 27, 2023

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165794 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072572 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi: 10.1074/jbc.275.8.5560 . PMID 10681536.
↑ Yamaguchi S (Jun 1995). "[Subtraction cloning of growth arrest inducible genes in normal human epithelial cells]". Kokubyo Gakkai Zasshi. 62 (1): 78–93. doi: 10.5357/koubyou.62.78 . PMID 7751801.
↑ "Entrez Gene: SLC39A2 solute carrier family 39 (zinc transporter), member 2".

Gong J, Xu J, Bezanilla M, et al. (1999). "Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2". Science. 285 (5433): 1565–9. doi:10.1126/science.285.5433.1565. PMID 10477520.
Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–35. doi: 10.1074/jbc.M205162200 . PMID 12431995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi: 10.1074/jbc.M304163200 . PMID 14525987.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Desouki MM, Geradts J, Milon B, et al. (2007). "hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands". Mol. Cancer. 6: 37. doi: 10.1186/1476-4598-6-37 . PMC 1892035 . PMID 17550612.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165794 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000072572 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10681536-5] Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi: 10.1074/jbc.275.8.5560 . PMID 10681536.

[pmid7751801-6] Yamaguchi S (Jun 1995). "[Subtraction cloning of growth arrest inducible genes in normal human epithelial cells]". Kokubyo Gakkai Zasshi. 62 (1): 78–93. doi: 10.5357/koubyou.62.78 . PMID 7751801.

[entrez-7] "Entrez Gene: SLC39A2 solute carrier family 39 (zinc transporter), member 2".

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Zinc transporter ZIP2

Contents

See also

Related Research Articles

References

Further reading