Zinc transporter ZIP2

SLC39A2
Identifiers
Aliases	SLC39A2 , 6A1, ETI-1, ZIP-2, ZIP2, solute carrier family 39 member 2
External IDs	OMIM: 612166; MGI: 2684326; HomoloGene: 40957; GeneCards: SLC39A2; OMA:SLC39A2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 20,999,255 bp [1] End 21,001,871 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C2 Start 52,130,346 bp [2] End 52,134,202 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg epithelium of esophagus gingival epithelium vulva cervix epithelium skin of arm seminal vesicula vagina palpebral conjunctiva Top expressed in cervix lip gastrula decidua vestibular membrane of cochlear duct olfactory epithelium blastocyst morula neural layer of retina primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion transmembrane transporter activity zinc ion transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane cytoplasmic vesicle Biological process metal ion transport zinc ion transport ion transport zinc ion transmembrane transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29986 214922 Ensembl ENSG00000165794 ENSMUSG00000072572 UniProt Q9NP94 G3X943 RefSeq (mRNA) NM_014579 NM_001256588 NM_001039676 RefSeq (protein) NP_001243517 NP_055394 NP_001034765 Location (UCSC) Chr 14: 21 – 21 Mb Chr 14: 52.13 – 52.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene. ^{[5] [6] [7]}

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000165794 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000072572 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi: 10.1074/jbc.275.8.5560 . PMID   10681536.
6. Yamaguchi S (Jun 1995). "[Subtraction cloning of growth arrest inducible genes in normal human epithelial cells]". Kokubyo Gakkai Zasshi. 62 (1): 78–93. doi: 10.5357/koubyou.62.78 . PMID   7751801.
7. "Entrez Gene: SLC39A2 solute carrier family 39 (zinc transporter), member 2".

Further reading

• Gong J, Xu J, Bezanilla M, et al. (1999). "Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2". Science. 285 (5433): 1565–9. doi:10.1126/science.285.5433.1565. PMID   10477520.
• Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–35. doi: 10.1074/jbc.M205162200 . PMID   12431995.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi: 10.1074/jbc.M304163200 . PMID   14525987.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Desouki MM, Geradts J, Milon B, et al. (2007). "hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands". Mol. Cancer. 6: 37. doi: 10.1186/1476-4598-6-37 . PMC   1892035 . PMID   17550612.