Zinc transporter ZIP6

SLC39A6
Identifiers
Aliases	SLC39A6 , LIV-1, ZIP6, solute carrier family 39 member 6, LIV1
External IDs	OMIM: 608731 MGI: 2147279 HomoloGene: 8199 GeneCards: SLC39A6
Gene location (Human)
Chr.	Chromosome 18 (human)
End	36,129,385 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	24,736,874 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; retinal pigment epithelium; ; hair follicle; ; tibia; ; seminal vesicula; ; caput epididymis; ; lactiferous duct; ; corpus epididymis; ; palpebral conjunctiva; ; parietal pleura;
	Top expressed in
	hair follicle; ; superior cervical ganglion; ; saccule; ; supraoptic nucleus; ; condyle; ; molar; ; fossa; ; otic placode; ; median eminence; ; motor neuron;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion transmembrane transporter activity ; zinc ion transmembrane transporter activity ;
Cellular component	integral component of membrane ; cell surface ; plasma membrane ; integral component of plasma membrane ; lamellipodium membrane ; endoplasmic reticulum ; membrane ;
Biological process	metal ion transport ; zinc ion transmembrane transport ; zinc ion transport ; zinc ion import across plasma membrane ; ion transport ; cellular zinc ion homeostasis ; transmembrane transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	25800
	106957
	ENSG00000141424
	ENSMUSG00000024270
	Q13433
	Q8C145
	NM_001099406 ; NM_012319
	NM_139143
	NP_001092876 ; NP_036451
	NP_631882
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 28, 2023

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.^[5]^[6]^[7]

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM]^[7]

Related Research Articles

Zinc transporter 8 (ZNT8) is a protein that in humans is encoded by the SLC30A8 gene. ZNT8 is a zinc transporter related to insulin secretion in humans. In particular, ZNT8 is critical for the accumulation of zinc into beta cell secretory granules and the maintenance of stored insulin as tightly-packaged hexamers. Certain alleles of the SLC30A8 gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.

Thiamine transporter 2 (ThTr-2), also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene. SLC19A3 is a thiamine transporter.

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.

Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.

CMP-sialic acid transporter is a protein that in humans is encoded by the SLC35A1 gene.

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.

Zinc transporter SLC39A7 (ZIP7), also known as solute carrier family 39 member 7, is a protein that in humans is encoded by the SLC39A7 gene. Its fruit fly orthologue is Catsup.

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.

Zinc transporter 7 is a protein that in humans is encoded by the SLC30A7 gene.

Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.

Solute carrier family 13 member 2 is a protein that is encoded in humans by the SLC13A2 gene.

Large neutral amino acids transporter small subunit 3 is a protein that in humans is encoded by the SLC43A1 gene.

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

Zinc transporter ZIP10, also known as solute carrier family 39 member 10, is a protein that in humans is encoded by the SLC39A10 gene. ZIP10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters, and have 14 members in the human genome: ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7, ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13 and ZIP14.

Solute carrier family 22 member 10 (SLC22A10), also known as organic anion transporter 5 (OAT5), is a protein that in humans is encoded by the SLC22A10 gene.

Zinc transporter ZIP9, also known as Zrt- and Irt-like protein 9 (ZIP9) and solute carrier family 39 member 9, is a protein that in humans is encoded by the SLC39A9 gene. This protein is the 9th member out of 14 ZIP family proteins, which is a membrane androgen receptor (mAR) coupled to G proteins, and also classified as a zinc transporter protein. ZIP family proteins transport zinc metal from the extracellular environment into cells through cell membrane.

Solute carrier family 39 member 12 is a protein that in humans is encoded by the SLC39A12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141424 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024270 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta. 1611 (1–2): 16–30. doi: 10.1016/S0005-2736(03)00048-8 . PMID 12659941.
↑ Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMC 1223660 . PMID 12839489.
1 2 "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

Manning DL, Daly RJ, Lord PG, et al. (1988). "Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line". Mol. Cell. Endocrinol. 59 (3): 205–12. doi:10.1016/0303-7207(88)90105-0. PMID 2903103. S2CID 23701658.
Dressman MA, Walz TM, Lavedan C, et al. (2002). "Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies". Pharmacogenomics J. 1 (2): 135–41. doi: 10.1038/sj.tpj.6500022 . PMID 11911440.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Schaner ME, Ross DT, Ciaravino G, et al. (2004). "Gene expression patterns in ovarian carcinomas". Mol. Biol. Cell. 14 (11): 4376–86. doi:10.1091/mbc.E03-05-0279. PMC 266758 . PMID 12960427.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kasper G, Weiser AA, Rump A, et al. (2005). "Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients". Int. J. Cancer. 117 (6): 961–73. doi: 10.1002/ijc.21235 . PMID 15986450. S2CID 43808796.
Zhao L, Chen W, Taylor KM, et al. (2007). "LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway". Biochem. Biophys. Res. Commun. 363 (1): 82–8. doi:10.1016/j.bbrc.2007.08.127. PMID 17825787.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141424 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024270 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12659941-5] Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta. 1611 (1–2): 16–30. doi: 10.1016/S0005-2736(03)00048-8 . PMID 12659941.

[pmid12839489-6] Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMC 1223660 . PMID 12839489.

[entrez-7] 1 2 "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

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Zinc transporter ZIP6

Contents

See also

Related Research Articles

References

Further reading