SLC4A4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | SLC4A4 , HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, pNBC, kNBC1, solute carrier family 4 member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603345; MGI: 1927555; HomoloGene: 55776; GeneCards: SLC4A4; OMA:SLC4A4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a membrane transport protein that in humans is encoded by the SLC4A4 gene. [5] [6] [7]
Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate co-transport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM] [7]
In the brain, the sodium bicarbonate transporter is predominantly expressed by astrocytes. [8] They may participate in regulation of brain extracellular space pH. [9] Some mutations in the gene have been associated with familial hemiplegic migraine. [10] Other mutations disrupt kidney bicarbonate transport and cause proximal renal tubular acidosis. [11]
NBCe1-A aka kNBC1 (mainly expressed in the kidney)
NBCe1-B aka pNBC1 (expressed in the pancreas and elsewhere)
NBCe1-C (expressed in the brain)
The renal SLC4A4 gene product NBCe1-A is specifically expressed in the basolateral membranes of proximal tubule epithelia.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.