Folate transporter 1

Last updated

SLC19A1
Identifiers
Aliases SLC19A1 , CHMD, FOLT, IFC1, REFC, RFC1, solute carrier family 19 member 1, IFC-1, RFC, hRFC, RFT-1, hMEGAF
External IDs OMIM: 600424; MGI: 103182; HomoloGene: 57139; GeneCards: SLC19A1; OMA:SLC19A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199271
NM_031196

RefSeq (protein)

NP_001186200
NP_112473

Location (UCSC) Chr 21: 45.49 – 45.57 Mb Chr 10: 77.03 – 77.06 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene. [5]

Contents

Function

Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate. [6] SLC19A1 has also been shown to transport the immune second messenger 2'3'-cGAMP. [7]

Clinical significance

Individuals carrying a specific polymorphism of SLC19A1 (c.80GG) have lower levels of folate. [8] Other studies have also shown that individuals carrying the c.80AA polymorphism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required.

Alternative names

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000173638 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001436 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lapenta V, Sossi V, Gosset P, Vayssettes C, Vitali T, Rabatel N, et al. (April 1998). "Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3". Genomics. 49 (1): 1–13. doi:10.1006/geno.1997.5185. PMID   9570943.
  6. "Entrez Gene: SLC19A1 solute carrier family 19 (folate transporter), member 1".
  7. Ritchie C, Cordova A, Hess G, Bassik M, Li L (25 July 2019). "SLC19A1 Is an Importer of the Immunotransmitter cGAMP". Molecular Cell. 75 (2): 372–381.e5. doi:10.1016/j.molcel.2019.05.006. PMC   6711396 . PMID   31126740.
  8. Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, et al. (September 2009). "The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women". Annals of Human Genetics. 73 (Pt 5): 484–491. doi:10.1111/j.1469-1809.2009.00529.x. PMC   2812009 . PMID   19650776.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.