HHC-acetate

HHC-acetate

Identifiers
IUPAC name [(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-yl] acetate
PubChem CID	165412103
UNII	FA3U4A4VSR
Chemical and physical data
Formula	C23H34O3
Molar mass	358.522 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCC1=CC2=C([C@@H]3CC(CC[C@H]3C(O2)(C)C)C)C(=C1)OC(=O)C
InChI InChI=1S/C23H34O3/c1-6-7-8-9-17-13-20(25-16(3)24)22-18-12-15(2)10-11-19(18)23(4,5)26-21(22)14-17/h13-15,18-19H,6-12H2,1-5H3/t15?,18-,19-/m1/s1 Key:ZAZIHGFBNRVMAI-JCNKGUCWSA-N

HHC-acetate (Hexahydrocannabinol-O-acetate, HHC-O) is a semi-synthetic cannabinoid derivative which has been marketed since around 2022. ^{[1] [2]}

Synthesis and chemistry

It is believed to be made in a three step process from cannabidiol extracted from industrial hemp by synthesis of Delta-8-THC from CBD, then hydrogenation of Delta-8-THC to Hexahydrocannabinol, then finally acetylation of HHC. ^[3]

Legality

The legal status of hexahydrocannabinol and derivatives such as HHC-O varies between countries leading to widespread sale in some jurisdictions in Europe and the US, but in France HHC and HHC-O were banned in 2023, and HHC is already banned in several other countries. ^[4] This molecule has also been banned in the Czech Republic. ^[5]

See also

• Abeo-HHC acetate
• Cannabidiol diacetate
• THC-O-acetate
• THCP-O-acetate
• Hexahydrocannabiphorol

References

1. Höfert L, Becker S, Dreßler J, Baumann S (August 2023). "Quantification of (9R)- and (9S)-hexahydrocannabinol (HHC) via GC-MS in serum/plasma samples from drivers suspected of cannabis consumption and immunological detection of HHC and related substances in serum, urine, and saliva". Drug Testing and Analysis. 16 (5): 489–497. doi: 10.1002/dta.3570 . PMID   37652872. S2CID   261430819.
2. Ujváry I. Hexahydrocannabinol and closely related semi-synthetic cannabinoids: A comprehensive review. Drug Testing and Analysis 2023. doi : 10.1002/dta.3519
3. "Hexahydrocannabinol (HHC) and related substances" (PDF). European Monitoring Centre for Drugs and Drug Addiction. 2023.
4. "Actualité - L'ANSM classe l'hexahydrocannabinol (HHC) et deux de ses dérivés sur la liste des stupéfiants". ANSM (in French). Retrieved 2023-06-12.
5. Fodor, Anna (2024-02-26). "EC confirms Czech government's decision to ban HHC". Radio Prague International.