| Heterolobosea | |
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| The three different stages of N. fowleri | |
Scientific classification  | |
| Domain: | Eukaryota |
| Phylum: | Percolozoa |
| Class: | Heterolobosea Page & Blanton 1985 |
| Orders | |
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Heterolobosea are a class of Percolozoa. The only member of this class that is infectious to humans is Naegleria fowleri , the causative agent of the often fatal disease amoebic meningitis. Typically, their life cycle alternates between flagellate and amoeboid stages.
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| | This section is empty. You can help by adding to it. (November 2024) |
The first broadly sampled comprehensive phylogenomic (phylotranscriptomic) analysis of the group (from 2025) confirmed the monophyly of Heterolobosea and provided a robustly supported backbone of the phylogeny resulting in the revision of the classification of Heterolobosea to the family level. [1]
The basal split of the cladogram has been confirmed between the subphyla Pharyngomonada (monotypic, with a sole family Pharyngomonadidae) and Tetramitia. In Tetramitia, two main clades (new classes) were identified: Selenaionea, consisting of two orders Neovahlkampfiida and Selenaionida in previously unsuspected but fully supported sister relationship, and Eutetramitea, consisting of orders Creneida, Lyromonadida, Naegleriida (new, including acrasid slime molds), Percolomonadida and Pseudociliatida (represented by the single genus Stephanopogon ; not included in the new analysis but analyses based on 18S rRNA gene sequences have repeatedly shown its close relationship to Percolomonadida with high statistical support): [1]
| Heterolobosea |
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These are collectively referred to as schizopyrenids, amoeboflagellates, or vahlkampfids. They also include the acrasids, a group of social amoebae that aggregate to form sporangia. The entire group is usually called the Heterolobosea, but this may be restricted to members with amoeboid stages.
One Heterolobosea classification system is: [2]
Pleurostomum flabellatum has recently been added to Heterolobosea. [3]
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