High affinity cationic amino acid transporter 1

SLC7A1
Identifiers
Aliases	SLC7A1 , ATRC1, CAT-1, ERR, HCAT1, REC1L, solute carrier family 7 member 1
External IDs	OMIM: 104615 MGI: 88117 HomoloGene: 20658 GeneCards: SLC7A1
Gene location (Human)
Chr.	Chromosome 13 (human)
End	29,595,688 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	148,336,714 bp
RNA expression pattern
	Top expressed in
	gums; ; endothelial cell; ; parotid gland; ; cavity of mouth; ; corpus epididymis; ; hair follicle; ; human penis; ; Brodmann area 23; ; retinal pigment epithelium; ; pons;
	Top expressed in
	cumulus cell; ; lacrimal gland; ; utricle; ; Paneth cell; ; hair follicle; ; condyle; ; conjunctival fornix; ; seminal vesicula; ; facial motor nucleus; ; semi-lunar valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; amino acid transmembrane transporter activity ; L-ornithine transmembrane transporter activity ; L-lysine transmembrane transporter activity ; transmembrane transporter activity ;
Cellular component	integral component of membrane ; integral component of plasma membrane ; membrane ; plasma membrane ; protein-containing complex ;
Biological process	amino acid transmembrane transport ; L-arginine transmembrane transport ; amino acid transport ; transport ; transmembrane transport ; L-arginine import across plasma membrane ; L-ornithine transmembrane transport ; L-lysine transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	6541
	11987
	ENSG00000139514
	ENSMUSG00000041313
	P30825
	Q09143
	NM_003045
	NM_001301424 ; NM_007513
	NP_003036
	NP_001288353 ; NP_031539
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 30, 2023

High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene.^[5]^[6]

Related Research Articles

The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 66 families. Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee (HGNC) and is the basis for the official HGNC names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB database.

CD98 is a glycoprotein that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain and aromatic amino acids. LAT is highly expressed in brain capillaries relative to other tissues.

Excitatory amino acid transporter 1 (EAAT1) is a protein that, in humans, is encoded by the SLC1A3 gene. EAAT1 is also often called the GLutamate ASpartate Transporter 1 (GLAST-1).

Thiamine transporter 1, also known as thiamine carrier 1 (TC1) or solute carrier family 19 member 2 (SLC19A2) is a protein that in humans is encoded by the SLC19A2 gene. SLC19A2 is a thiamine transporter. Mutations in this gene cause thiamine-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness.

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 gene.

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.

Excitatory amino acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene.

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.

Y+L amino acid transporter 1 is a protein that in humans is encoded by the SLC7A7 gene.

An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.

Monocarboxylate transporter 1 is a ubiquitous protein that in humans is encoded by the SLC16A1 gene. It is a proton coupled monocarboxylate transporter.

Cationic amino acid transporter 2 is a protein that in humans is encoded by the SLC7A2 gene.

Cationic amino acid transporter 4 is a protein that in humans is encoded by the SLC7A4 gene.

Sodium-dependent neutral amino acid transporter B(0)AT1 is a protein that in humans is encoded by the SLC6A19 gene.

The plasma membrane monoamine transporter (PMAT) is a low-affinity monoamine transporter protein which in humans is encoded by the SLC29A4 gene. It is known alternatively as the human equilibrative nucleoside transporter-4 (hENT4). Unlike other members of the ENT family, it is impermeable to most nucleosides, with the exception of the inhibitory neurotransmitter and ribonucleoside adenosine, which it is permeable to in a highly pH-dependent manner.

Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that in humans is encoded by the SLC7A5 gene.

Y+L amino acid transporter 2, also known as cationic amino acid transporter, y+ system, is a protein that in humans is encoded by the SLC7A6 gene.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

The proton-coupled folate transporter is a protein that in humans is encoded by the SLC46A1 gene. The major physiological roles of PCFTs are in mediating the intestinal absorption of folate, and its delivery to the central nervous system.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139514 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041313 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Albritton LM, Bowcock AM, Eddy RL, Morton CC, Tseng L, Farrer LA, Cavalli-Sforza LL, Shows TB, Cunningham JM (March 1992). "The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14". Genomics. 12 (3): 430–4. doi:10.1016/0888-7543(92)90431-Q. PMID 1348489.
↑ "Entrez Gene: SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1".

Yoshimoto T, Yoshimoto E, Meruelo D (November 1991). "Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor". Virology. 185 (1): 10–7. doi: 10.1016/0042-6822(91)90748-Z . PMID 1718082.
Kamath SG, Furesz TC, Way BA, Smith CH (September 1999). "Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1". The Journal of Membrane Biology. 171 (1): 55–62. doi:10.1007/s002329900558. PMID 10485994. S2CID 25084494.
Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818. S2CID 30892800.
Cariappa R, Heath-Monnig E, Furesz TC, Kamath SG, Smith CH (March 2002). "Stable polarized expression of hCAT-1 in an epithelial cell line". The Journal of Membrane Biology. 186 (1): 23–30. doi:10.1007/s00232-001-0133-y. PMID 11891586. S2CID 25743745.
Furesz TC, Heath-Monnig E, Kamath SG, Smith CH (September 2002). "Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes". The Journal of Membrane Biology. 189 (1): 27–33. doi:10.1007/s00232-002-1001-0. PMID 12202949. S2CID 24776183.
Kizhatil K, Albritton LM (December 2002). "System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells". American Journal of Physiology. Cell Physiology. 283 (6): C1784-94. doi:10.1152/ajpcell.00061.2002. PMID 12388095. S2CID 17848190.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Schnorr O, Suschek CV, Kolb-Bachofen V (June 2003). "The importance of cationic amino acid transporter expression in human skin". The Journal of Investigative Dermatology. 120 (6): 1016–22. doi: 10.1046/j.1523-1747.2003.12139.x . PMID 12787129.
González M, Flores C, Pearson JD, Casanello P, Sobrevia L (July 2004). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells". Pflügers Archiv. 448 (4): 383–94. doi:10.1007/s00424-004-1261-x. PMID 15064952. S2CID 25238852.
Schwartz IF, Iaina A, Benedict Y, Wollman Y, Chernichovski T, Brasowski E, Misonzhnik F, Ben-Dor A, Blum M, Levo Y, Schwartz D (April 2004). "Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats". Kidney International. 65 (4): 1311–9. doi: 10.1111/j.1523-1755.2004.00508.x . PMID 15086470.
Rotmann A, Strand D, Martiné U, Closs EI (December 2004). "Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity". The Journal of Biological Chemistry. 279 (52): 54185–92. doi: 10.1074/jbc.M409556200 . PMID 15491978.
Cui Z, Tuladhar R, Hart SL, Marber MS, Pearson JD, Baydoun AR (February 2005). "Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells". Nitric Oxide. 12 (1): 21–30. doi:10.1016/j.niox.2004.11.001. hdl: 2299/1712 . PMID 15631944.
Yang Z, Venardos K, Jones E, Morris BJ, Chin-Dusting J, Kaye DM (March 2007). "Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction". Circulation. 115 (10): 1269–74. doi: 10.1161/CIRCULATIONAHA.106.665836 . PMID 17325243.
Kaneko S, Okuda-Ashitaka E, Ando A, Nishimura K, Igarashi K, Maeda M, Furuta K, Suzuki M, Matsumura M, Ito S (August 2007). "Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells". American Journal of Physiology. Cell Physiology. 293 (2): C729-37. doi:10.1152/ajpcell.00018.2007. PMID 17494634. S2CID 9039432.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000139514 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041313 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1348489-5] Albritton LM, Bowcock AM, Eddy RL, Morton CC, Tseng L, Farrer LA, Cavalli-Sforza LL, Shows TB, Cunningham JM (March 1992). "The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14". Genomics. 12 (3): 430–4. doi:10.1016/0888-7543(92)90431-Q. PMID 1348489.

[entrez-6] "Entrez Gene: SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1".

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High affinity cationic amino acid transporter 1

Contents

See also

Related Research Articles

References

Further reading