Large neutral amino acids transporter small subunit 1

SLC7A5
Identifiers
Aliases	SLC7A5 , 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1, solute carrier family 7 member 5
External IDs	OMIM: 600182; MGI: 1298205; HomoloGene: 55759; GeneCards: SLC7A5; OMA:SLC7A5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q24.2 Start 87,830,023 bp [1] End 87,869,507 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 E1|8 Start 122,607,889 bp [2] End 122,634,433 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium beta cell dorsal motor nucleus of vagus nerve mucosa of pharynx inferior olivary nucleus mucosa of esophagus body of tongue corpus epididymis left testis right testis Top expressed in lacrimal gland fetal liver hematopoietic progenitor cell lens seminal vesicula spermatocyte calvaria optic nerve parotid gland seminiferous tubule blood More reference expression data BioGPS n/a
Gene ontology Molecular function peptide antigen binding L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity antiporter activity protein binding transmembrane transporter activity Cellular component integral component of membrane membrane intracellular membrane-bounded organelle plasma membrane apical plasma membrane extracellular exosome integral component of plasma membrane cytoplasm cytosol Biological process amino acid transmembrane transport cell differentiation cellular amino acid metabolic process nervous system development multicellular organism development L-amino acid transport neutral amino acid transport leukocyte migration amino acid transport L-alpha-amino acid transmembrane transport transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8140 20539 Ensembl ENSG00000103257 ENSMUSG00000040010 UniProt Q01650 Q9Z127 RefSeq (mRNA) NM_003486 NM_011404 RefSeq (protein) NP_003477 NP_035534 Location (UCSC) Chr 16: 87.83 – 87.87 Mb Chr 8: 122.61 – 122.63 Mb PubMed search [3] [4]
Wikidata
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Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that in humans is encoded by the SLC7A5 gene. ^{[5] [6]}

See also

• Heterodimeric amino acid transporter

References

1. GRCh38: Ensembl release 89: ENSG00000103257 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040010 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".
6. "UniProt". www.uniprot.org.

Further reading

• Kaira K, Oriuchi N, Imai H, et al. (2009). "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma". Lung Cancer. 66 (1): 120–6. doi:10.1016/j.lungcan.2008.12.015. PMID   19171406.
• Verrey F, Jack DL, Paulsen IT, et al. (1999). "New glycoprotein-associated amino acid transporters". J. Membr. Biol. 172 (3): 181–92. doi:10.1007/s002329900595. PMID   10568788. S2CID   25962115.
• Nawashiro H, Otani N, Shinomiya N, et al. (2006). "L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors". Int. J. Cancer. 119 (3): 484–92. doi: 10.1002/ijc.21866 . PMID   16496379. S2CID   41965333.
• Nawashiro H, Otani N, Uozumi Y, et al. (2005). "High expression of L-type amino acid transporter 1 in infiltrating glioma cells". Brain Tumor Pathol. 22 (2): 89–91. doi:10.1007/s10014-005-0188-z. PMID   18095110. S2CID   22818900.
• Ohno Y, Suda K, Masuko K, et al. (2008). "Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1". Cancer Sci. 99 (5): 1000–7. doi: 10.1111/j.1349-7006.2008.00770.x . PMC   11160021 . PMID   18294274. S2CID   205233796.
• Vumma R, Wiesel FA, Flyckt L, et al. (2008). "Functional characterization of tyrosine transport in fibroblast cells from healthy controls". Neurosci. Lett. 434 (1): 56–60. doi:10.1016/j.neulet.2008.01.028. PMID   18262359. S2CID   25493412.
• Endou H, Kanai Y (1999). "[Amino acid transporter molecule as a drug target]". Nippon Yakurigaku Zasshi. 114 (Suppl 1): 11P –16P. doi: 10.1254/fpj.114.supplement_11 . PMID   10629848.
• Nakanishi K, Ogata S, Matsuo H, et al. (2007). "Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract". Virchows Arch. 451 (3): 681–90. doi:10.1007/s00428-007-0457-9. PMID   17622555. S2CID   2540836.
• Kaira K, Oriuchi N, Imai H, et al. (2009). "L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas". J Surg Oncol. 99 (7): 433–8. doi:10.1002/jso.21277. PMID   19347882. S2CID   5381963.
• Anderson BM, Schnetz-Boutaud NC, Bartlett J, et al. (2009). "Examination of association of genes in the serotonin system to autism". Neurogenetics. 10 (3): 209–16. doi:10.1007/s10048-009-0171-7. PMC   2753863 . PMID   19184136.
• Ring BZ, Seitz RS, Beck RA, et al. (2009). "A novel five-antibody immunohistochemical test for subclassification of lung carcinoma". Mod. Pathol. 22 (8): 1032–43. doi: 10.1038/modpathol.2009.60 . PMID   19430419.
• Kaira K, Oriuchi N, Imai H, et al. (2008). "Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung". Pathol. Res. Pract. 204 (8): 553–61. doi:10.1016/j.prp.2008.02.003. PMID   18440724.
• Kobayashi K, Ohnishi A, Promsuk J, et al. (2008). "Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells". Neurosurgery. 62 (2): 493–503, discussion 503–4. doi:10.1227/01.neu.0000316018.51292.19. PMID   18382329.
• Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics. 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID   17558306. S2CID   25402443.
• Kaira K, Oriuchi N, Imai H, et al. (2008). "Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer". Br. J. Cancer. 98 (4): 742–8. doi:10.1038/sj.bjc.6604235. PMC   2259171 . PMID   18253116.
• Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID   18195088.
• Kaira K, Oriuchi N, Imai H, et al. (2008). "l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms". Cancer Sci. 99 (12): 2380–6. doi: 10.1111/j.1349-7006.2008.00969.x . PMC   11159766 . PMID   19018776. S2CID   24560556.
• Imai H, Kaira K, Oriuchi N, et al. (2009). "L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer". Histopathology. 54 (7): 804–13. doi:10.1111/j.1365-2559.2009.03300.x. PMID   19635099. S2CID   5787861.
• Shennan DB, Thomson J (2008). "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells". Oncol. Rep. 20 (4): 885–9. doi: 10.3892/or_00000087 . PMID   18813831.
• Sakata T, Ferdous G, Tsuruta T, et al. (2009). "L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer". Pathol. Int. 59 (1): 7–18. doi:10.1111/j.1440-1827.2008.02319.x. PMID   19121087. S2CID   32050759.