SLC47A1

SLC47A1
Identifiers
Aliases	SLC47A1 , MATE1, solute carrier family 47 member 1
External IDs	MGI: 1914723 HomoloGene: 34364 GeneCards: SLC47A1
Gene location (Human)
Chr.	Chromosome 17 (human) [1]
End	19,579,034 bp [1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse) [2]
End	61,378,345 bp [2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• antiporter activity ; • drug:proton antiporter activity ; • monovalent cation:proton antiporter activity ; • drug transmembrane transporter activity ;
Cellular component	• integral component of membrane ; • plasma membrane ; • membrane ; • vesicle ;
Biological process	• hydrogen ion transmembrane transport ; • drug transport ; • transmembrane transport ; • drug export ; • drug transmembrane transport ; • organic cation transport ; • cation transport ;
	Sources:Amigo / QuickGO
Orthologs
	55244
	67473
	ENSG00000142494
	ENSMUSG00000010122
	Q96FL8
	Q8K0H1
	NM_018242
	NM_026183
	NP_060712
	NP_080459
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 23, 2019

‹ The template Infobox gene is being considered for merging. ›

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47, member 1, is a protein that in humans is encoded by the SLC47A1 gene.^[5]^[6] SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.^[7]^[8]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Gene

The SLC47A1 gene is located within the Smith-Magenis syndrome region on chromosome 17.^[5]

Function

SLC47A1 is a member of the MATE family of transporters that excrete endogenous and exogenous toxic electrolytes through urine and bile.^[6]

Discovery

The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its homologue from E. coli were identified in 1998, which is the first of Solute carrier family 47 member.^[7] NorM seems to function as drug/sodium antiporter which is the first example of Na⁺-coupled multidrug efflux transporter.^[9] NorM is a prototype of a new transporter family and Brown et al. named it the multidrug and toxic compound extrusion family.^[8] The X-ray structure of the transporter NorM was determined to 3.65 Å, revealing an outward-facing conformation with two portals open to the outer leaflet of the membrane and a unique topology of the predicted 12 transmembrane helices distinct from any other known multidrug resistance transporter.^[10]

Active efflux is a mechanism responsible for moving compounds, like neurotransmitters, toxic substances, and antibiotics, out of cells; a process considered to be a vital part of xenobiotic metabolism. This mechanism is important in medicine as it can contribute to bacterial antibiotic resistance.

A membrane transport protein is a membrane protein involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane. Transport proteins are integral transmembrane proteins; that is they exist permanently within and span the membrane across which they transport substances. The proteins may assist in the movement of substances by facilitated diffusion or active transport. The two main types of proteins involved in such transport are broadly categorized as either channels or carriers. The solute carriers and atypical SLCs are secondary active or facilitative transporters in humans.

Vibrio parahaemolyticus is a curved, rod-shaped, Gram-negative bacterium found in brackish, saltwater, which, when ingested, causes gastrointestinal illness in humans. V. parahaemolyticus is oxidase positive, facultatively aerobic, and does not form spores. Like other members of the genus Vibrio, this species is motile, with a single, polar flagellum.

Related Research Articles

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the OSTA gene.

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.

SLC46A1, (solute carrier family 46 member 1), is the gene in humans that enodes the protein proton-coupled folate transporter.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Solute carrier family 47, member 2, also known as SLC47A2, is a protein which in humans is encoded by the SLC47A2 gene.

Multi-antimicrobial extrusion protein (MATE) also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters.

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

Solute carrier family 22 member 25 (SLC22A25), also known as organic anion transporter UST6, is a protein that in humans is encoded by the SLC22A25 gene.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) flippase superfamily is a group of integral membrane protein families. The MOP flippase superfamily includes twelve distantly related families, six for which functional data are available:

One ubiquitous family (MATE) specific for drugs - (TC# 2.A.66.1) The Multi Antimicrobial Extrusion (MATE) Family
One (PST) specific for polysaccharides and/or their lipid-linked precursors in prokaryotes - (TC# 2.A.66.2) The Polysaccharide Transport (PST) Family
One (OLF) specific for lipid-linked oligosaccharide precursors of glycoproteins in eukaryotes - (TC# 2.A.66.3) The Oligosaccharidyl-lipid Flippase (OLF) Family
One (MVF) lipid-peptidoglycan precursor flippase involved in cell wall biosynthesis - (TC# 2.A.66.4) The Mouse Virulence Factor (MVF) Family
One (AgnG) which includes a single functionally characterized member that extrudes the antibiotic, Agrocin 84 - (TC# 2.A.66.5) The Agrocin 84 Antibiotic Exporter (AgnG) Family
And finally, one (Ank) that shuttles inorganic pyrophosphate (PP_i) - (TC# 2.A.66.9) The Progressive Ankylosis (Ank) Family

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142494 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010122 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: FLJ10847 hypothetical protein FLJ10847".
1 2 Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y (December 2005). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923–8. doi:10.1073/pnas.0506483102. PMC 1312386 . PMID 16330770.
1 2 Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, Tsuchiya T (July 1998). "NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli". Antimicrob. Agents Chemother. 42 (7): 1778–82. doi:10.1128/AAC.42.7.1778. PMC 105682 . PMID 9661020.
1 2 Brown MH, Paulsen IT, Skurray RA (January 1999). "The multidrug efflux protein NorM is a prototype of a new family of transporters". Mol. Microbiol. 31 (1): 394–5. doi:10.1046/j.1365-2958.1999.01162.x. PMID 9987140.
↑ Morita Y, Kataoka A, Shiota S, Mizushima T, Tsuchiya T (December 2000). "NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump". J. Bacteriol. 182 (23): 6694–7. doi:10.1128/JB.182.23.6694-6697.2000. PMC 111412 . PMID 11073914.
↑ He X, Szewczyk P, Karykin A, Hong WX, Zhang Q, Chang G (2010). "Structure of a cation-bound multidrug and toxic compound extrusion transporter". Nature. 467 (7318): 991–4. doi:10.1038/nature09408. PMC 3152480 . PMID 20861838.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594 . PMID 11997338.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Otsuka M, Matsumoto T, Morimoto R, et al. (2006). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923–8. doi:10.1073/pnas.0506483102. PMC 1312386 . PMID 16330770.
Ohta KY, Inoue K, Hayashi Y, Yuasa H (2006). "Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney". Drug Metab. Dispos. 34 (11): 1868–74. doi:10.1124/dmd.106.010876. PMID 16928787.
Omote H, Hiasa M, Matsumoto T, et al. (2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations". Trends Pharmacol. Sci. 27 (11): 587–93. doi:10.1016/j.tips.2006.09.001. PMID 16996621.
Tsuda M, Terada T, Asaka J, et al. (2007). "Oppositely directed H+ gradient functions as a driving force of rat H+/organic cation antiporter MATE1". Am. J. Physiol. Renal Physiol. 292 (2): F593–8. doi:10.1152/ajprenal.00312.2006. PMID 17047166.
Chen Y, Zhang S, Sorani M, Giacomini KM (2007). "Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family". J. Pharmacol. Exp. Ther. 322 (2): 695–700. doi:10.1124/jpet.107.123554. PMID 17495125.
Tanihara Y, Masuda S, Sato T, et al. (2007). "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters". Biochem. Pharmacol. 74 (2): 359–71. doi:10.1016/j.bcp.2007.04.010. PMID 17509534.
Kajiwara M, Terada T, Asaka J, et al. (2007). "Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1". Am. J. Physiol. Renal Physiol. 293 (5): F1564–70. doi:10.1152/ajprenal.00322.2007. PMID 17855482.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142494 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010122 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] 1 2 "Entrez Gene: FLJ10847 hypothetical protein FLJ10847".

[pmid16330770-6] 1 2 Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y (December 2005). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923–8. doi:10.1073/pnas.0506483102. PMC 1312386 . PMID 16330770.

[pmid9661020-7] 1 2 Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, Tsuchiya T (July 1998). "NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli". Antimicrob. Agents Chemother. 42 (7): 1778–82. doi:10.1128/AAC.42.7.1778. PMC 105682 . PMID 9661020.

[pmid9987140-8] 1 2 Brown MH, Paulsen IT, Skurray RA (January 1999). "The multidrug efflux protein NorM is a prototype of a new family of transporters". Mol. Microbiol. 31 (1): 394–5. doi:10.1046/j.1365-2958.1999.01162.x. PMID 9987140.

[pmid11073914-9] Morita Y, Kataoka A, Shiota S, Mizushima T, Tsuchiya T (December 2000). "NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump". J. Bacteriol. 182 (23): 6694–7. doi:10.1128/JB.182.23.6694-6697.2000. PMC 111412 . PMID 11073914.

[pmid20861838-10] He X, Szewczyk P, Karykin A, Hong WX, Zhang Q, Chang G (2010). "Structure of a cation-bound multidrug and toxic compound extrusion transporter". Nature. 467 (7318): 991–4. doi:10.1038/nature09408. PMC 3152480 . PMID 20861838.

SLC47A1

Contents

Gene

Function

Discovery

See also

Related Research Articles

References

Further reading