SLC9A2

SLC9A2
Identifiers
Aliases	SLC9A2 , NHE2, solute carrier family 9 member A2
External IDs	MGI: 105075 HomoloGene: 20661 GeneCards: SLC9A2
Gene location (Human)
Chr.	Chromosome 2 (human) [1]
End	102,711,318 bp [1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse) [2]
End	40,769,273 bp [2]
Gene ontology
Molecular function	• solute:proton antiporter activity ; • antiporter activity ; • potassium:proton antiporter activity ; • sodium:proton antiporter activity ;
Cellular component	• integral component of membrane ; • membrane ; • plasma membrane ;
Biological process	• hydrogen ion transmembrane transport ; • protein localization ; • cation transport ; • ion transport ; • regulation of pH ; • sodium ion transport ; • regulation of intracellular pH ; • sodium ion import across plasma membrane ; • potassium ion transmembrane transport ; • transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	6549
	226999
	ENSG00000115616
	ENSMUSG00000026062
	Q9UBY0
	n/a
	NM_003048
	NM_001033289
	NP_003039
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 19, 2019

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.^[5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Related Research Articles

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The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.

Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed to interact via long-range allostery, involving significant protein dynamics.

Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY-interacting protein 1 (SIP-1) is a protein that in humans is encoded by the SLC9A3R2 gene.

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.

Electrogenic sodium bicarbonate cotransporter 1 is a membrane transport protein that in humans is encoded by the SLC4A4 gene.

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. AE2 is functionally similar to the Band 3 Cl⁻/HCO3⁻ exchange protein.

Solute carrier family 22 member 3 (SLC22A3) also known as the organic cation transporter 3 (OCT3) or extraneuronal monoamine transporter (EMT) is a protein that in humans is encoded by the SLC22A3 gene.

Calcineurin B homologous protein 1 is protein encoded in humans by the CHP1 gene.

Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl⁻/HCO3⁻ exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have been linked to seizures.

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.

Sodium–hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.

Urea transporter, kidney also known as urea transporter 2 (UT2) or solute carrier family 14 member 2 (SLC14A2) is a protein that in humans is encoded by the SLC14A2 gene.

Sodium/hydrogen exchanger 8 is a protein that in humans is encoded by the SLC9A8 gene.

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.

Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein that in humans is encoded by the GNAT3 gene.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

References

Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3". Clinical and investigative medicine. Médecine clinique et experimentale. 22 (5): 195–206. PMID 10579058.
Kulanthaivel P, Furesz TC, Moe AJ, et al. (1992). "Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane". Biochem. J. 284 (1): 33–8. PMC 1132693  . PMID 1318024.
Collins JF, Honda T, Knobel S, et al. (1993). "Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2)". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 3938–42. doi:10.1073/pnas.90.9.3938. PMC 46421  . PMID 7683411.
Ghishan FK, Knobel SM, Summar M (1996). "Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2)". Genomics. 30 (1): 25–30. doi:10.1006/geno.1995.0004. PMID 8595899.
Dudeja PK, Rao DD, Syed I, et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA". Am. J. Physiol. 271 (3 Pt 1): G483–93. PMID 8843774.
Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044  . PMID 8901634.
"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Chow CW, Woodside M, Demaurex N, et al. (1999). "Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia". J. Biol. Chem. 274 (15): 10481–8. doi:10.1074/jbc.274.15.10481. PMID 10187839.
Malakooti J, Dahdal RY, Schmidt L, et al. (1999). "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2". Am. J. Physiol. 277 (2 Pt 1): G383–90. PMID 10444453.
Malakooti J, Dahdal RY, Dudeja PK, et al. (2001). "The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (4): G763–73. PMID 11254504.
Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
Repishti M, Hogan DL, Pratha V, et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. PMID 11408268.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241  . PMID 12477932.
Lacey HA, Nolan T, Greenwood SL, et al. (2005). "Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR". Placenta. 26 (1): 93–8. doi:10.1016/j.placenta.2004.05.005. PMID 15664417.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Pearse I, Zhu YX, Murray EJ, et al. (2007). "Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site". Biochem. J. 407 (1): 101–11. doi:10.1042/BJ20070364. PMC 2267401  . PMID 17561809.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115616 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026062 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2".

SLC9A2

Contents

See also

Related Research Articles

References

Further reading