OR10G4

OR10G4
Identifiers
Aliases	OR10G4 , OR11-278, olfactory receptor family 10 subfamily G member 4
External IDs	MGI: 3030814 HomoloGene: 81557 GeneCards: OR10G4
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.2 Start 124,012,997 bp [1] End 124,018,732 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.1 Start 39,915,644 bp [2] End 39,920,878 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas placenta rectum testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process signal transduction response to stimulus sensory perception of smell detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390264 259110 Ensembl ENSG00000254737 ENSMUSG00000060254 UniProt Q8NGN3 Q8VH08 RefSeq (mRNA) NM_001004462 NM_147106 RefSeq (protein) NP_001004462 NP_667317 Location (UCSC) Chr 11: 124.01 – 124.02 Mb Chr 9: 39.92 – 39.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 10G4 is a protein that in humans is encoded by the OR10G4 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Genetic differences

Nonsynonymous substitutions in the OR10G4 gene have a significant effect on the perception of the "smoky" odorant guaiacol. Individuals with mutations that reduce the affinity of the OR10G4 receptor for guaiacol have a reduced sensitivity to it, and the same people who report guaiacol as weaker tend to rate it as more pleasant. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000254737 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060254 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR10G4 olfactory receptor, family 10, subfamily G, member 4".
6. Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC   3990440 . PMID   24316890.

Further reading

• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR10G4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.