OR8B12

OR8B12
Identifiers
Aliases	OR8B12 , OR11-317, olfactory receptor family 8 subfamily B member 12
External IDs	MGI: 3030708; HomoloGene: 17377; GeneCards: OR8B12; OMA:OR8B12 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.2 Start 124,539,635 bp [1] End 124,545,333 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A4 Start 37,656,402 bp [2] End 37,659,890 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle multicellular organism Top expressed in secondary oocyte spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity odorant binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 219858 258882 Ensembl ENSG00000170953 ENSMUSG00000063350 UniProt Q8NGG6 Q7TRE6 RefSeq (mRNA) NM_001005195 NM_146882 RefSeq (protein) NP_001005195 NP_667093 Location (UCSC) Chr 11: 124.54 – 124.55 Mb Chr 9: 37.66 – 37.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 8B12 is a protein that in humans is encoded by the OR8B12 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000170953 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063350 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR8B12 olfactory receptor, family 8, subfamily B, member 12".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.135.3652 . doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR8B12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.