OR2L13

OR2L13
Identifiers
Aliases	OR2L13 , OR2L14, olfactory receptor family 2 subfamily L member 13
External IDs	MGI: 3030000 HomoloGene: 88350 GeneCards: OR2L13
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 248,095,184 bp [1] End 248,101,103 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A3 Start 19,302,444 bp [2] End 19,308,632 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 hypothalamus endothelial cell substantia nigra putamen caudate nucleus nucleus accumbens amygdala hippocampus proper n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity protein binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284521 259071 Ensembl ENSG00000196071 ENSMUSG00000056822 UniProt Q8N349 Q8VGX2 RefSeq (mRNA) NM_001304535 NM_175911 NM_001395936 NM_147068 RefSeq (protein) NP_001291464 NP_787107 NP_667279 Location (UCSC) Chr 1: 248.1 – 248.1 Mb Chr 16: 19.3 – 19.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2L13 is a protein that in humans is encoded by the OR2L13 gene. ^[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5] OR2L13 was recently implicated in regulating platelet reactivity and growth of abdominal aortic aneurysms ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000196071 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056822 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR2L13 olfactory receptor, family 2, subfamily L, member 13".
6. Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P, et al. (May 2022). "Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms". The Journal of Clinical Investigation. 132 (9). doi:10.1172/JCI152373. PMC   9057618 . PMID   35324479.

External links

• OR2L13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.