OR1B1

OR1B1
Identifiers
Aliases	OR1B1 , OR9-26, OR9-B, olfactory receptor family 1 subfamily B member 1 (gene/pseudogene), olfactory receptor family 1 subfamily B member 1
External IDs	MGI: 3030196 HomoloGene: 17479 GeneCards: OR1B1
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q33.2 Start 122,628,579 bp [1] End 122,629,573 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 36,991,718 bp [2] End 37,007,922 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta endometrium cervix lymph node right lung gallbladder superior frontal gyrus canal of the cervix Top expressed in spermatid testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity transmembrane signaling receptor activity olfactory receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 347169 259053 Ensembl ENSG00000280094 ENSMUSG00000075377 UniProt Q8NGR6 Q8VGV7 RefSeq (mRNA) NM_001004450 NM_147051 RefSeq (protein) NP_001004450 NP_667262 Location (UCSC) Chr 9: 122.63 – 122.63 Mb Chr 2: 36.99 – 37.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 1B1 is a protein that in humans is encoded by the OR1B1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

As of 2015, OR1B1 was an orphan receptor, meaning that no odorants have been identified which bind to it. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000280094 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075377 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR1B1 olfactory receptor, family 1, subfamily B, member 1".
6. de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.

External links

• OR1B1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.