OR2T1

OR2T1
Identifiers
Aliases	OR2T1 , OR1-25, olfactory receptor family 2 subfamily T member 1
External IDs	MGI: 109304 HomoloGene: 74028 GeneCards: OR2T1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 248,403,048 bp [1] End 248,408,020 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A1 Start 8,137,972 bp [2] End 8,146,935 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in brain prefrontal cortex cerebral cortex multicellular organism Top expressed in hypothalamus spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26696 18330 Ensembl ENSG00000275244 ENSG00000273508 ENSG00000175143 ENSMUSG00000072707 UniProt O43869 n/a RefSeq (mRNA) NM_030904 NM_147027 RefSeq (protein) NP_112166 n/a Location (UCSC) Chr 1: 248.4 – 248.41 Mb Chr 14: 8.14 – 8.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2T1 is a protein that in humans is encoded by the OR2T1 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. ENSG00000273508, ENSG00000175143 GRCh38: Ensembl release 89: ENSG00000275244, ENSG00000273508, ENSG00000175143 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000072707 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID   9500546. S2CID   31129045.
6. "Entrez Gene: OR2T1 olfactory receptor, family 2, subfamily T, member 1".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2T1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.