OR2A5

OR2A5
Identifiers
Aliases	OR2A5 , OR2A11P, OR2A26, OR2A8, OR7-138, OR7-141, olfactory receptor family 2 subfamily A member 5
External IDs	MGI: 3030282 HomoloGene: 64846 GeneCards: OR2A5
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q35 Start 144,048,948 bp [1] End 144,058,845 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.1 Start 42,867,375 bp [2] End 42,876,019 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa rectum muscle tissue skeletal muscle tissue smooth muscle tissue gallbladder fundus thymus islet of Langerhans ganglionic eminence n/a More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 393046 258270 Ensembl ENSG00000221836 ENSG00000284896 ENSMUSG00000043119 UniProt Q96R48 Q8VES9 RefSeq (mRNA) NM_012365 NM_146273 RefSeq (protein) NP_036497 NP_666385 Location (UCSC) Chr 7: 144.05 – 144.06 Mb Chr 6: 42.87 – 42.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2A5 is a protein that in humans is encoded by the OR2A5 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. ENSG00000284896 GRCh38: Ensembl release 89: ENSG00000221836, ENSG00000284896 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043119 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID   9500546. S2CID   31129045.
6. "Entrez Gene: OR2A5 olfactory receptor, family 2, subfamily A, member 5".

Further reading

• Fuchs T; Malecova B; Linhart C; et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.

External links

• OR2A5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.