OR4B1

OR4B1
Identifiers
Aliases	OR4B1 , OR11-106, OST208, olfactory receptor family 4 subfamily B member 1
External IDs	MGI: 109303 HomoloGene: 110550 GeneCards: OR4B1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 48,216,810 bp [1] End 48,217,739 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 89,966,617 bp [2] End 89,972,640 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in olfactory bulb BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 119765 18331 Ensembl ENSG00000175619 ENSMUSG00000075066 UniProt Q8NGF8 n/a RefSeq (mRNA) NM_001005470 NM_010980 RefSeq (protein) NP_001005470 n/a Location (UCSC) Chr 11: 48.22 – 48.22 Mb Chr 2: 89.97 – 89.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 4B1 is a protein that in humans is encoded by the OR4B1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000175619 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075066 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4B1 olfactory receptor, family 4, subfamily B, member 1".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4B1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.