OR3A1

OR3A1
Identifiers
Aliases	OR3A1 , OLFRA03, OR17-40, OR17-82, OR40, olfactory receptor family 3 subfamily A member 1, olfactory receptor family 3 subfamily A member 1 (gene/pseudogene)
External IDs	MGI: 3030236 HomoloGene: 1915 GeneCards: OR3A1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.3 Start 3,291,017 bp [1] End 3,298,360 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 74,044,355 bp [2] End 74,048,987 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte islet of Langerhans prefrontal cortex urinary bladder testicle gallbladder adrenal gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4994 258703 Ensembl ENSG00000180090 ENSMUSG00000070379 UniProt P47881 Q8VFX8 RefSeq (mRNA) NM_002550 NM_146708 RefSeq (protein) NP_002541 NP_666919 Location (UCSC) Chr 17: 3.29 – 3.3 Mb Chr 11: 74.04 – 74.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene. ^{[5] [6] [7]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[7]

Ligands

OR3A1 is activated by helional and the closely related molecule heliotropylacetone. ^[8] Other compounds including piperonal, safrole, and vanillin completely failed to activate OR3A1.

Agonists:

• helional ^[8]
• heliotropylacetone ^[8]
• lilial ^[9]
• cyclamen aldehyde ^[9]
• foliaver (3-(4-methoxyphenyl)-2-methylpropanal) ^[9]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000180090 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070379 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Glusman G, Clifton S, Roe B, Lancet D (October 1996). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics. 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID   8921386.
6. Crowe ML, Perry BN, Connerton IF (March 1996). "Olfactory receptor-encoding genes and pseudogenes are expressed in humans". Gene. 169 (2): 247–9. doi:10.1016/0378-1119(95)00849-7. PMID   8647456.
7. "Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1".
8. Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi:10.1093/chemse/bji002. PMID   15647465.
9. Jacquier V, Pick H, Vogel H (April 2006). "Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds". Journal of Neurochemistry. 97 (2): 537–44. doi: 10.1111/j.1471-4159.2006.03771.x . PMID   16539658. S2CID   22179276.

Further reading

• Marrakchi M, Vidic J, Jaffrezic-Renault N, Martelet C, Pajot-Augy E (November 2007). "A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40". European Biophysics Journal. 36 (8): 1015–8. doi:10.1007/s00249-007-0187-6. PMID   17579849. S2CID   11099976.
• Jacquier V, Prummer M, Segura JM, Pick H, Vogel H (September 2006). "Visualizing odorant receptor trafficking in living cells down to the single-molecule level". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14325–30. Bibcode:2006PNAS..10314325J. doi: 10.1073/pnas.0603942103 . PMC   1599963 . PMID   16980412.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
• Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, et al. (February 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Human Molecular Genetics. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID   8004088.

External links

• OR3A1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.