OR2D2

OR2D2
Identifiers
Aliases	OR2D2 , OR11-610, OR2D1, hg27, olfactory receptor family 2 subfamily D member 2
External IDs	OMIM: 608494 MGI: 3647188 HomoloGene: 81541 GeneCards: OR2D2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 6,891,574 bp [1] End 6,892,500 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 106,702,955 bp [2] End 106,709,576 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube endocrine system endocrine gland thyroid gland left lobe of thyroid gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 120776 384732 Ensembl ENSG00000166368 ENSMUSG00000062987 UniProt Q9H210 E9Q725 RefSeq (mRNA) NM_003700 NM_001162940 RefSeq (protein) NP_003691 NP_001156412 Location (UCSC) Chr 11: 6.89 – 6.89 Mb Chr 7: 106.7 – 106.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2D2 is a protein that in humans is encoded by the OR2D2 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000166368 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062987 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Buettner JA, Glusman G, Ben-Arie N, Ramos P, Lancet D, Evans GA (Dec 1998). "Organization and evolution of olfactory receptor genes on human chromosome 11". Genomics. 53 (1): 56–68. doi:10.1006/geno.1998.5422. PMID   9787077.
6. "Entrez Gene: OR2D2 olfactory receptor, family 2, subfamily D, member 2".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2D2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.