OR51B4

OR51B4
Identifiers
Aliases	OR51B4 , HOR5'Beta1, olfactory receptor family 51 subfamily B member 4
External IDs	MGI: 1341906 HomoloGene: 88376 GeneCards: OR51B4
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,301,014 bp [1] End 5,301,946 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 103,528,650 bp [2] End 103,535,459 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Right adrenal gland fallopian tube myometrium canal of the cervix tibial nerve smooth muscle tissue blood right coronary artery ascending aorta left coronary artery n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79339 18367 Ensembl ENSG00000183251 ENSMUSG00000058200 UniProt Q9Y5P0 F8VQ01 RefSeq (mRNA) NM_033179 NM_013618 RefSeq (protein) NP_149419 NP_038646 Location (UCSC) Chr 11: 5.3 – 5.3 Mb Chr 7: 103.53 – 103.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 51B4 is a protein that in humans is encoded by the OR51B4 gene. ^[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000183251 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058200 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR51B4 olfactory receptor, family 51, subfamily B, member 4".

Further reading

• Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH (April 1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi: 10.1073/pnas.96.9.5129 . PMC   21828 . PMID   10220430.
• Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R (December 2000). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi: 10.1073/pnas.97.26.14560 . PMC   18958 . PMID   11121057.

External links

• OR51B4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.