OR51M1

OR51M1
Identifiers
Aliases	OR51M1 , HOR5'Beta7, OR11-40, olfactory receptor family 51 subfamily M member 1
External IDs	MGI: 3030465 HomoloGene: 64935 GeneCards: OR51M1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,383,812 bp [1] End 5,393,263 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 103,578,032 bp [2] End 103,578,991 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve kidney tibial nerve brain prefrontal cortex multicellular organism cerebral cortex n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390059 258961 Ensembl ENSG00000184698 ENSMUSG00000042219 UniProt Q9H341 F8VPJ9 RefSeq (mRNA) NM_001004756 NM_001271020 NM_146959 RefSeq (protein) NP_001004756 NP_001257949 Location (UCSC) Chr 11: 5.38 – 5.39 Mb Chr 7: 103.58 – 103.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 51M1 is a protein that in humans is encoded by the OR51M1 gene. ^[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. ^[6] The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000184698 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042219 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR51M1 olfactory receptor, family 51, subfamily M, member 1".
6. Knape K, Beyer A, Stary A, Buchbauer G, Wolschann P (2008). "Genomics of selected human odorant receptors". Chemical Monthly. 139 (12): 1537–1544. doi: 10.1007/s00706-008-0957-6 .

Further reading

• Bulger M, van Doorninck JH, Saitoh N, et al. (1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi: 10.1073/pnas.96.9.5129 . PMC   21828 . PMID   10220430.
• Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. doi: 10.1073/pnas.97.26.14560 . PMC   18958 . PMID   11121057.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR51M1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.