OR56A4

OR56A4
Identifiers
Aliases	OR56A4 , OR11-49, olfactory receptor family 56 subfamily A member 4
External IDs	MGI: 3030518 HomoloGene: 133596 GeneCards: OR56A4
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,999,445 bp [1] End 6,006,946 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 104,803,899 bp [2] End 104,812,860 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in organ system reproductive system reproductive organ gonad male reproductive system testicle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity adrenergic receptor activity dopamine neurotransmitter receptor activity, coupled via Gi/Go dopamine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane synaptic vesicle membrane Biological process adenylate cyclase-activating adrenergic receptor signaling pathway sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus synaptic transmission, dopaminergic negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway response to toxic substance regulation of dopamine secretion regulation of potassium ion transport behavioral response to cocaine behavioral response to ethanol negative regulation of cytosolic calcium ion concentration negative regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway negative regulation of voltage-gated calcium channel activity G protein-coupled receptor signaling pathway adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 120793 244187 Ensembl ENSG00000183389 ENSMUSG00000047225 UniProt Q8NGH8 Q7TRN8 RefSeq (mRNA) NM_001005179 NM_207249 RefSeq (protein) NP_001005179 NP_997132 Location (UCSC) Chr 11: 6 – 6.01 Mb Chr 7: 104.8 – 104.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 56A4 is a protein that in humans is encoded by the OR56A4 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

• Decanal ^[6]
• Undecanal ^[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000183389 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047225 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR56A4 olfactory receptor, family 56, subfamily A, member 4".
6. Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi: 10.1371/journal.pgen.1002821 . PMC   3395614 . PMID   22807691.
7. Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC   3990440 . PMID   24316890.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR56A4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.