OR4D1

OR4D1
Identifiers
Aliases	OR4D1 , OR17-23, OR4D3, OR4D4P, TPCR16, olfactory receptor family 4 subfamily D member 1
External IDs	MGI: 3030298 HomoloGene: 44975 GeneCards: OR4D1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q22 Start 58,148,384 bp [1] End 58,159,585 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 C Start 87,804,094 bp [2] End 87,811,793 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node blood cecum pharynx appendix spleen thymus Top expressed in secondary oocyte hypothalamus superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity olfactory receptor activity Cellular component membrane plasma membrane integral component of membrane Biological process detection of chemical stimulus involved in sensory perception signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26689 258407 Ensembl ENSG00000141194 ENSMUSG00000060787 UniProt Q15615 Q5SW48 RefSeq (mRNA) NM_012374 NM_001386095 NM_146412 RefSeq (protein) NP_036506 NP_666524 Location (UCSC) Chr 17: 58.15 – 58.16 Mb Chr 11: 87.8 – 87.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 4D1 is a protein that in humans is encoded by the OR4D1 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000141194 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060787 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (Apr 1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics. 39 (3): 239–46. doi:10.1006/geno.1996.4490. PMID   9119360.
6. "Entrez Gene: OR4D1 olfactory receptor, family 4, subfamily D, member 1".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4D1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.