OR2L2

OR2L2
Identifiers
Aliases	OR2L2 , HSHTPCRH07, HTPCRH07, OR1-48, OR2L12, OR2L4P, olfactory receptor family 2 subfamily L member 2
External IDs	MGI: 3030001 HomoloGene: 78689 GeneCards: OR2L2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 248,030,070 bp [1] End 248,042,305 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A3 Start 19,328,308 bp [2] End 19,341,016 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex ganglionic eminence substantia nigra hippocampus proper testicle putamen hypothalamus Brodmann area 9 spleen amygdala n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity molecular function Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26246 258937 Ensembl ENSG00000203663 ENSMUSG00000045341 UniProt Q8NH16 Q8VGJ5 RefSeq (mRNA) NM_001004686 NM_001385855 NM_146935 RefSeq (protein) NP_001004686 NP_667146 Location (UCSC) Chr 1: 248.03 – 248.04 Mb Chr 16: 19.33 – 19.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2L2 is a protein that in humans is encoded by the OR2L2 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000203663 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045341 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID   1370859. S2CID   43926.
6. "Entrez Gene: OR2L2 olfactory receptor, family 2, subfamily L, member 2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• OR2L2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.