OR1D2

OR1D2
Identifiers
Aliases	OR1D2 , OLFR1, OR17-4, olfactory receptor family 1 subfamily D member 2
External IDs	OMIM: 164342 MGI: 3030246 HomoloGene: 37634 GeneCards: OR1D2
Gene location (Mouse) Chr. Chromosome 11 (mouse) [1] Band 11|11 B5 Start 74,252,895 bp [1] End 74,257,044 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell tibialis anterior muscle lower lobe of lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity identical protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process chemotaxis sensory perception of smell signal transduction single fertilization response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4991 258153 Ensembl n/a ENSMUSG00000058275 UniProt P34982 Q7TRW7 RefSeq (mRNA) NM_002548 NM_001386088 NM_001011851 RefSeq (protein) NP_002539 NP_001011851 Location (UCSC) n/a Chr 11: 74.25 – 74.26 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene. ^{[4] [5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

Expression

As well as bring expressed in the olfactory epithelium of the human nose, OR1D2 is special in that it is also expressed in human spermatozoa, where it is involved in sperm chemotaxis. ^[7]

Ligands

Bourgeonal is a reported ligand for OR1D2 that affects sperm chemotaxis. ^[7]

Ligands include: ^[7]

• Bourgeonal
• Canthoxal
• Cyclamal
• Floralazone
• Lilial
• Phenylacetaldehyde
• 3-phenylbutyraldehyde
• 3-phenylpropionaldehyde
• 4-phenylbutyraldehyde
• (p-tert-butylphenoxy)acetaldehyde

See also

• Olfactory receptor

References

1. GRCm38: Ensembl release 89: ENSMUSG00000058275 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID   1370859. S2CID   43926.
5. Buck L, Axel R (May 1991). "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition". Cell. 65 (1): 175–87. doi: 10.1016/0092-8674(91)90418-X . PMID   1840504.
6. "Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2".
7. Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (March 2003). "Identification of a testicular odorant receptor mediating human sperm chemotaxis". Science. 299 (5615): 2054–8. Bibcode:2003Sci...299.2054S. doi:10.1126/science.1080376. PMID   12663925. S2CID   45306091.

Further reading

• Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J (1992). "Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences". Brain Res. Mol. Brain Res. 13 (1–2): 159–63. doi:10.1016/0169-328X(92)90057-I. PMID   1315913.
• Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID   8004088.
• Schurmans S, Muscatelli F, Miot F, et al. (1993). "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13→p12 region of the human genome and reveals an MspI restriction fragment length polymorphism". Cytogenet. Cell Genet. 63 (3): 200–4. doi:10.1159/000133534. PMID   8097991.
• Nekrasova E, Sosinskaya A, Natochin M, et al. (1996). "Overexpression, solubilization and purification of rat and human olfactory receptors". Eur. J. Biochem. 238 (1): 28–37. doi: 10.1111/j.1432-1033.1996.0028q.x . PMID   8665947.
• Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Spehr M, Gisselmann G, Poplawski A, et al. (2003). "Identification of a testicular odorant receptor mediating human sperm chemotaxis". Science. 299 (5615): 2054–8. Bibcode:2003Sci...299.2054S. doi:10.1126/science.1080376. PMID   12663925. S2CID   45306091.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• OR1D2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.