OR6A2

OR6A2
Identifiers
Aliases	OR6A2 , I7, OR11-55, OR6A1, OR6A2P, olfactory receptor family 6 subfamily A member 2
External IDs	OMIM: 608495 MGI: 97432 HomoloGene: 2743 GeneCards: OR6A2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 6,791,736 bp [1] End 6,799,689 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 106,594,606 bp [2] End 106,605,279 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in organ system reproductive system reproductive organ male reproductive system gonad testicle Top expressed in Jacobson's organ secondary oocyte yolk sac peripheral nervous system vastus lateralis muscle respiratory epithelium olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8590 18317 Ensembl ENSG00000184933 ENSMUSG00000070417 UniProt O95222 n/a RefSeq (mRNA) NM_003696 NM_010983 RefSeq (protein) NP_003687 n/a Location (UCSC) Chr 11: 6.79 – 6.8 Mb Chr 7: 106.59 – 106.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene. ^[5] It is Class II (tetrapod-specific) olfactory receptor and a rhodopsin-like receptor.

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. ^[5]

Clinical significance

Variation in the OR6A2 gene has been identified as a likely cause of why some people enjoy the smell and taste of coriander (also known as cilantro) ^[6] while others have exactly the opposite reaction to the point of repulsion. Depending on ancestry, somewhere between 3% and 21% of the population associate it with unpleasant taste, including a combination of soap and vomit, or say that it is similar to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals, which are present in soap, various detergents, coriander, several species of stinkbugs and cinnamon. ^[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000184933 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070417 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
6. Eriksson N; Wu S; Chuong BD; et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv: 1209.2096 . doi: 10.1186/2044-7248-1-22 . S2CID   199627.
7. Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi:10.1038/nature.2012.11398. S2CID   87980895.

Further reading

• Buettner JA, Glusman G, Ben-Arie N, et al. (1998). "Organization and evolution of olfactory receptor genes on human chromosome 11". Genomics. 53 (1): 56–68. doi:10.1006/geno.1998.5422. PMID   9787077.
• Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode:2001PNAS...98.7390L. doi: 10.1073/pnas.131215398 . PMC   34679 . PMID   11416212.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• OR6A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.