OR51B2

OR51B2
Identifiers
Aliases	OR51B2 , HOR5'Beta3, OR51B1P, olfactory receptor family 51 subfamily B member 2 (gene/pseudogene), olfactory receptor family 51 subfamily B member 2
External IDs	MGI: 1341900 HomoloGene: 56593 GeneCards: OR51B2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,323,359 bp [1] End 5,324,297 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 103,538,692 bp [2] End 103,543,692 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle pancreatic ductal cell deltoid muscle Achilles tendon lower lobe of lung Top expressed in submandibular gland sternocleidomastoid muscle temporal muscle tibialis anterior muscle vastus lateralis muscle median eminence More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79345 18366 Ensembl ENSG00000279012 ENSMUSG00000063615 UniProt Q9Y5P1 F8VPZ8 RefSeq (mRNA) NM_033180 NM_013617 RefSeq (protein) NP_149420 NP_038645 Location (UCSC) Chr 11: 5.32 – 5.32 Mb Chr 7: 103.54 – 103.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 51B2 is a protein that in humans is encoded by the OR51B2 gene. ^[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

As of 2015, OR51B2 was an orphan receptor, meaning that no odorants have been identified which bind to it. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000279012 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063615 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR51B2 olfactory receptor, family 51, subfamily B, member 2".
6. de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.

Further reading

• Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH (April 1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi: 10.1073/pnas.96.9.5129 . PMC   21828 . PMID   10220430.
• Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R (December 2000). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi: 10.1073/pnas.97.26.14560 . PMC   18958 . PMID   11121057.
• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.

External links

• OR51B2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.