OR12D2

OR12D2
Identifiers
Aliases	OR12D2 , DJ994E9.8, HS6M1-20, olfactory receptor family 12 subfamily D member 2 (gene/pseudogene), olfactory receptor family 12 subfamily D member 2
External IDs	MGI: 2177484 HomoloGene: 133728 GeneCards: OR12D2
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 29,395,631 bp [1] End 29,398,008 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 37,608,447 bp [2] End 37,615,204 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hypothalamus hippocampus proper caudate nucleus temporal lobe amygdala Brodmann area 9 nucleus accumbens Top expressed in spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26529 258831 Ensembl ENSG00000280236 ENSMUSG00000092077 UniProt P58182 Q920Z0 RefSeq (mRNA) NM_013936 NM_146834 RefSeq (protein) NP_039224 NP_667045 Location (UCSC) Chr 6: 29.4 – 29.4 Mb Chr 17: 37.61 – 37.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor, family 12, subfamily D, member 2, also known as OR12D2, is a protein which in humans is encoded by the OR12D2 gene. ^[5]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000280236 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000092077 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR12D2 olfactory receptor, family 12, subfamily D, member 2".

Further reading

• Younger RM, Amadou C, Bethel G, et al. (2001). "Characterization of clustered MHC-linked olfactory receptor genes in human and mouse". Genome Res. 11 (4): 519–30. doi:10.1101/gr.gr-1603r. PMC   311051 . PMID   11282967.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.