OR1E1

OR1E1
Identifiers
Aliases	OR1E1 , HGM071, OR13-66, OR17-2, OR17-32, OR1E5, OR1E6, OR1E8P, OR1E9P, OST547, olfactory receptor family 1 subfamily E member 1
External IDs	HomoloGene: 74111 GeneCards: OR1E1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.3 Start 3,397,104 bp [1] End 3,398,410 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle placenta mammary gland breast prefrontal cortex temporal lobe tibial nerve sigmoid colon heart ventricle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity olfactory receptor activity Cellular component membrane plasma membrane integral component of membrane Biological process detection of chemical stimulus involved in sensory perception signal transduction response to stimulus sensory perception of smell detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8387 n/a Ensembl ENSG00000180016 n/a UniProt P30953 n/a RefSeq (mRNA) NM_003553 n/a RefSeq (protein) NP_003544 n/a Location (UCSC) Chr 17: 3.4 – 3.4 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 1E1 is a protein that in humans is encoded by the OR1E1 gene. ^{[3] [4] [5]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000180016 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H, et al. (Jul 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum Mol Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID   8004088.
4. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID   1370859. S2CID   43926.
5. "Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1".

Further reading

• Rouquier S, Taviaux S, Trask BJ, et al. (1998). "Distribution of olfactory receptor genes in the human genome". Nat. Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID   9500546. S2CID   31129045.
• Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
• Rouquier S, Blancher A, Giorgi D (2000). "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2870–4. Bibcode:2000PNAS...97.2870R. doi: 10.1073/pnas.040580197 . PMC   16022 . PMID   10706615.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR1E1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.