OR9A4

OR9A4
Identifiers
Aliases	OR9A4 , olfactory receptor family 9 subfamily A member 4
External IDs	MGI: 3030294 HomoloGene: 64866 GeneCards: OR9A4
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q34 Start 141,916,399 bp [1] End 141,920,625 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B1 Start 40,546,421 bp [2] End 40,551,277 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow monocyte right coronary artery blood reproductive system reproductive organ gonad male reproductive system testicle Top expressed in secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function olfactory receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 130075 258381 Ensembl ENSG00000258083 ENSMUSG00000045514 UniProt Q8NGU2 Q8VF31 RefSeq (mRNA) NM_001001656 NM_146383 RefSeq (protein) NP_001001656 NP_666495 Location (UCSC) Chr 7: 141.92 – 141.92 Mb Chr 6: 40.55 – 40.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 9A4 is a protein that in humans is encoded by the OR9A4 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000258083 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045514 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR9A4 olfactory receptor, family 9, subfamily A, member 4".

Further reading

• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR9A4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.