OR2A1

OR2A1
Identifiers
Aliases	OR2A1 , olfactory receptor family 2 subfamily A member 1
External IDs	MGI: 3030269 HomoloGene: 110586 GeneCards: OR2A1
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q35 Start 144,312,419 bp [1] End 144,322,737 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.1 Start 43,174,080 bp [2] End 43,180,563 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon left lobe of thyroid gland right lobe of thyroid gland stromal cell of endometrium bone marrow ovary thymus right lung left uterine tube n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 346528 258647 Ensembl ENSG00000221970 ENSMUSG00000048693 UniProt Q8NGT9 Q8VFS3 RefSeq (mRNA) NM_001005287 NM_146653 RefSeq (protein) NP_001005287 NP_666864 Location (UCSC) Chr 7: 144.31 – 144.32 Mb Chr 6: 43.17 – 43.18 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 2A1/2A42 is a protein that in humans is encoded by the OR2A1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000221970 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048693 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR2A1 olfactory receptor, family 2, subfamily A, member 1".

Further reading

• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2A1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.