OR2W1

OR2W1
Identifiers
Aliases	OR2W1 , hs6M1-15, olfactory receptor family 2 subfamily W member 1
External IDs	MGI: 3030097 HomoloGene: 12791 GeneCards: OR2W1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 29,044,213 bp [1] End 29,045,175 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.1 Start 21,313,809 bp [2] End 21,320,466 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26692 18341 Ensembl ENSG00000204704 ENSG00000226463 ENSG00000206525 ENSG00000228977 ENSG00000228652 ENSG00000229328 ENSG00000227639 ENSG00000234101 ENSMUSG00000071522 UniProt Q9Y3N9 Q7TQT8 RefSeq (mRNA) NM_030903 NM_010984 RefSeq (protein) NP_112165 NP_035114 Location (UCSC) Chr 6: 29.04 – 29.05 Mb Chr 13: 21.31 – 21.32 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 2W1 is a protein that in humans is encoded by the OR2W1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

Out of 10 human ORs studied, OR2W1 was the most broadly tuned, meaning it responds to the greatest variety of different odorant molecules. ^[6]

Ligands, in decreasing order of sensitivity: ^[6]

• 2-Heptanone
• 1-Octanal
• (-)-Citronellol
• Hexanal
• 3-Octanone
• Hexyl acetate
• 1-Hexanol
• Octanoic acid
• 1-Heptanol
• Allyl phenylacetate
• Benzyl acetate ^[7]
• 3,4-Hexanedione

See also

• Olfactory receptor

References

1. ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 GRCh38: Ensembl release 89: ENSG00000204704, ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071522 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR2W1 olfactory receptor, family 2, subfamily W, member 1".
6. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC   2774247 . PMID   19261596.
7. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi: 10.1371/journal.pone.0093037 . PMC   3973694 . PMID   24695519.

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.135.3652 . doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2W1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.